AI Article Synopsis
Article Abstract
Hepatocyte growth factor receptor (HGFR), also known as c-mesenchymal-epithelial transition factor (c-MET), plays a crucial role in the carcinogenesis of epithelial ovarian cancer (EOC). In contrast, the mechanisms contributing to aberrant expression of HGFR in EOC are not fully understood. In the present study, the expression of HGFR with its prognostic and predictive role was evaluated immunohistochemically in a cohort of 42 primary ovarian cancer patients. Furthermore, we analyzed the dual expression of HGFR and other druggable biomarkers. In the multivariate Cox regression analysis, high HGFR expression was identified as an independent prognostic factor for a shorter progression-free survival (PFS) (hazard ratio (HR) 2.99, 95% confidence interval (CI95%) 1.01-8.91, = 0.049) and overall survival (OS) (HR 5.77, CI95% 1.56-21.34, = 0.009). In addition, the combined expression of HGFR, human epidermal growth factor receptor 2 (Her2/neu), epithelial growth factor receptor (EGFR), insulin-like growth factor 1 (IGF1R), Mucin-1 and Integrin α2β1 further significantly impaired PFS, platinum-free interval (PFI) and OS. Protein co-expression analyses were confirmed by transcriptomic data in a large, independent cohort of patients. In conclusion, new biomarker-directed treatment targets were identified to fight poor prognosis of primary EOC.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687566 | PMC |
| http://dx.doi.org/10.3390/biomedicines10112694 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
HGF-HGFR-STAT signaling axis regulates haemocyte proliferation in oyster Crassostrea gigas.
Dev Comp Immunol
January 2025
Liaoning Key Laboratory of Marine Animal Immunology and Disease Control, Dalian Ocean University, Dalian, 116023, China; Southern Laboratory of Ocean Science and Engineering (Guangdong, Zhuhai), Zhuhai, 519000, China; Liaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University, Dalian, 116023, China; Dalian Key Laboratory of Aquatic Animal Disease Prevention and Control, Dalian Ocean University, Dalian, 116023, China. Electronic address:
Article Synopsis
- The study identified a homologue of hepatocyte growth factor (CgHGF-like) and its receptor (CgHGFR) in the oyster Crassostrea gigas, which are involved in cell growth and division.
- Both genes are expressed in all tested tissues, with the highest levels found in haemocytes, and their expression significantly increases when the oysters are stimulated with Vibrio splendidus.
- The interaction between CgHGF-like and CgHGFR plays a crucial role in regulating haemocyte proliferation during immune responses, primarily by activating the CgSTAT pathway.
c-MET and the immunological landscape of cancer: novel therapeutic strategies for enhanced anti-tumor immunity.
Front Immunol
December 2024
Department of Biochemistry, Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland.
Article Synopsis
- - c-MET, or hepatocyte growth factor receptor (HGFR), is a key protein linked to various types of solid tumors and is associated with poorer treatment outcomes due to its connection to therapeutic resistance and expression alongside PD-L1.
- - Tumor cells and myeloid-derived suppressor cells (MDSCs) activate c-MET signaling through hepatocyte growth factor (HGF), which disrupts immune function by depleting crucial amino acids, ultimately creating an immunosuppressive tumor environment.
- - The review discusses potential c-MET-targeted immunotherapies, such as CAR therapies and monoclonal antibodies, highlighting their promise in improving cancer treatment and the importance of understanding the underlying molecular mechanisms for developing effective
Membrane Receptor-Mediated Disruption of Cellular Homeostasis: Changes in Intracellular Signaling Pathways Increase the Toxicity of Ochratoxin A.
Mol Nutr Food Res
July 2024
Department of Biology, Molecular Biology Section, Akdeniz University, Antalya, 07070, Turkey.
Organisms maintain their cellular homeostatic balance by interacting with their environment through the use of their cell surface receptors. Membrane based receptors such as the transforming growth factor β receptor (TGFR), the prolactin receptor (PRLR), and hepatocyte growth factor receptor (HGFR), along with their associated signaling cascade, play significant roles in retaining cellular homeostasis. While these receptors and related signaling pathways are essential for health of cell and organism, their dysregulation can lead to imbalance in cell function with severe pathological conditions such as cell death or cancer.
View Article and Find Full Text PDFRegeneration of Non-Alcoholic Fatty Liver Cells Using Chimeric FGF21/HGFR: A Novel Therapeutic Approach.
Int J Mol Sci
March 2024
Department of Biochemistry, Inha University School of Medicine, Incheon 22212, Republic of Korea.
Non-alcoholic fatty liver disease (NAFLD) has emerged as a significant liver ailment attributed to factors like obesity and diabetes. While ongoing research explores treatments for NAFLD, further investigation is imperative to address this escalating health concern. NAFLD manifests as hepatic steatosis, precipitating insulin resistance and metabolic syndrome.
View Article and Find Full Text PDFTargeting the PI3K/pAKT/mTOR/NF-κB/FOXO3a signaling pathway for suppressing the development of hepatocellular carcinoma in rats: Role of the natural remedic Suaeda vermiculata forssk.
Environ Toxicol
June 2024
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Egypt.
Liver malignancy is well recognized as a prominent health concern, with numerous treatment options available. Natural products are considered a renewable source, providing inspiring chemical moieties that could be used for cancer treatment. Suaeda vermiculata Forssk has traditionally been employed for management of hepatic conditions, including liver inflammation, and liver cirrhosis, as well as to improve general liver function.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!