AI Article Synopsis
- CYP3A is a subfamily of enzymes in the cytochrome P450 superfamily, which includes several isoforms like CYP3A4 and CYP3A5.
- These enzymes are versatile, metabolizing a wide range of substances, including both naturally occurring compounds and various drugs, mainly characterized by their lipophilicity and large size.
- The review discusses how CYP3A enzymes function under normal physiological conditions and their role in disease development and progression.
Article Abstract
CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate toward substrates and are unique in that these enzymes metabolize both endogenous compounds and diverse xenobiotics (including drugs); almost the only common characteristic of these compounds is lipophilicity and a relatively large molecular weight. CYP3A enzymes are widely expressed in human organs and tissues, and consequences of these enzymes' activities play a major role both in normal regulation of physiological levels of endogenous compounds and in various pathological conditions. This review addresses these aspects of regulation of CYP3A enzymes under physiological conditions and their involvement in the initiation and progression of diseases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687714 | PMC |
| http://dx.doi.org/10.3390/biomedicines10112686 | DOI Listing |
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