AI Article Synopsis
- Protein kinase C (PKC) is a family of at least 11 isozymes categorized into three subfamilies based on their structure and activation mechanisms: classic (cPKCs), non-classic (nPKCs), and atypical (aPKCs).
- PKC isozymes are crucial in various cellular processes related to cancer, influencing factors like growth, survival, and drug resistance, and have been linked to poorer outcomes in cancer patients, such as reduced disease-free survival and higher recurrence rates.
- The review discusses the potential of PKC isozymes as biomarkers for cancer diagnosis and prognosis, highlighting their prospects as therapeutic targets.
Article Abstract
Protein kinase C (PKC) is a large family of calcium- and phospholipid-dependent serine/threonine kinases that consists of at least 11 isozymes. Based on their structural characteristics and mode of activation, the PKC family is classified into three subfamilies: conventional or classic (cPKCs; α, βI, βII, and γ), novel or non-classic (nPKCs; δ, ε, η, and θ), and atypical (aPKCs; ζ, ι, and λ) (PKCλ is the mouse homolog of PKCι) PKC isozymes. PKC isozymes play important roles in proliferation, differentiation, survival, migration, invasion, apoptosis, and anticancer drug resistance in cancer cells. Several studies have shown a positive relationship between PKC isozymes and poor disease-free survival, poor survival following anticancer drug treatment, and increased recurrence. Furthermore, a higher level of PKC activation has been reported in cancer tissues compared to that in normal tissues. These data suggest that PKC isozymes represent potential diagnostic and prognostic biomarkers and therapeutic targets for cancer. This review summarizes the current knowledge and discusses the potential of PKC isozymes as biomarkers in the diagnosis, prognosis, and treatment of cancers.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658272 | PMC |
| http://dx.doi.org/10.3390/cancers14215425 | DOI Listing |
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