Global, Regional, and National Burdens with Temporal Trends of Early-, Intermediate-, and Later-Onset Gastric Cancer from 1990 to 2019 and Predictions up to 2035.

Fei-Long Ning Nan-Nan Zhang Zhe-Ming Zhao Wan-Ying Du Yong-Ji Zeng Masanobu Abe Jun-Peng Pei Chun-Dong Zhang

Cancers (Basel)

Department of Gastrointestinal Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang 110032, China.

Published: November 2022

The study focuses on the trends and impact of early-onset, intermediate-onset, and later-onset gastric cancer using data from 2019, revealing significant differences in incidence and mortality rates across various demographics.
From 1990 to 2019, early-onset gastric cancer (EOGC) declined more slowly than other types, with projections indicating a substantial increase in EOGC cases from 2020 to 2035, while intermediate-onset is expected to remain stable.
The findings underline the need for targeted cancer-control strategies, especially for underrepresented groups like those with early-onset gastric cancer, to address their unique health burdens.

Background: Evidence for estimating and predicting the temporal trends of gastric cancer in different age groups is lacking.

Methods: Data of early-, intermediate-, and later-onset gastric cancer (EOGC, IOGC, LOGC) was from the Global Burden of Diseases Study 2019. The incidences and deaths due to EOGC, IOGC, and LOGC were analyzed by period, sex, geographic location, and sociodemographic incidence. Temporal trends were evaluated by estimated annual percentage changes (EAPCs). The incidences and temporal trends were predicted until 2035.

Results: There were substantial differences in the incidence and death rates of the three populations at global, regional and national levels in 2019. From 1990 to 2019, EOGC (EAPC, -0.84) showed a slower decrease in incidence rate worldwide than IOGC (EAPC, -1.77) and LOGC (EAPC, -1.10), whereas EOGC and LOGC showed slower decreases in mortality than IOGC. The worldwide incidence rate of EOGC (EAPC, 1.44) was predicted to increase substantially from 2020 to 2035, while that for LOGC (EAPC, 0.43) was predicted to increase slightly and that for IOGC (EAPC, -0.01) was predicted to remain stable over the same period.

Conclusions: This study revealed differences in the burdens and temporal trends of EOGC, IOGC, and LOGC, and highlighted the importance of tailored cancer-control measures in neglected subpopulations, especially in patients with EOGC.

Download full-text PDF	Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656932	PMC
http://dx.doi.org/10.3390/cancers14215417	DOI Listing

Publication Analysis

Top Keywords

temporal trends

gastric cancer

eogc iogc

iogc logc

global regional

regional national

burdens temporal

early- intermediate-

intermediate- later-onset

later-onset gastric

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!