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D609 Suppresses Antituberculosis Response by Regulating Dendritic Cells Antigen Presentation.
Immun Inflamm Dis
December 2024
Department of Clinical Laboratory, Zhongshan Second People's Hospital, Zhongshan, Guangdong, China.
Objective: To elucidate the role of phosphatidylcholine-specific phospholipase C (PC-PLC) in the antituberculosis (anti-TB) immune response mediated by dendritic cells (DCs).
Methods: In vivo, C57BL/6J mice infected with the Mycobacterium tuberculosis strain H37Rv. Before infection, the mice were pretreated with the PC-PLC inhibitor D609.
A Recombinant Strain Expressing ETEC Heat-Labile Enterotoxin B Subunit Shows Promise for Vaccine Development via OMVs.
Int J Mol Sci
November 2024
Department of Microbiology and Parasitology, Navarra Medical Research Institute (IdiSNA), University of Navarra, 31008 Pamplona, Spain.
Diarrheal diseases caused by and enterotoxigenic (ETEC) are significant health burdens, especially in resource-limited regions with high child mortality. In response to the lack of licensed vaccines and rising antibiotic resistance for these pathogens, this study developed a recombinant strain with the novel incorporation of the gene for the heat-labile enterotoxin B (LTB) subunit of ETEC directly into 's genome, enhancing stability and consistent production. This approach combines the immunogenic potential of LTB with the antigen delivery properties of outer membrane vesicles (OMVs), aiming to provide cross-protection against both bacterial pathogens in a stable, non-replicating vaccine platform.
View Article and Find Full Text PDFEnhanced autophagy and cholesterol efflux in mouse mesenchymal stem cells infected with H37Rv compared to H37Ra.
Microb Pathog
December 2024
Clinical Translational Research Center, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China; Shanghai TB Key Laboratory, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China; TB Department, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China; Department of Microbiology and Immunology, Tongji University School of Medicine, Shanghai 200092, China. Electronic address:
Autophagy, metabolism, and associated signaling pathways play critical roles in bacterial survival within mammalian cells and influence the immunopathogenesis of infections. Mesenchymal stem cells (MSCs) are important host cells during Mycobacterium tuberculosis (Mtb) infection, yet how autophagy, metabolism, and related pathways are modulated in MSCs infected with the virulent H37Rv or the attenuated H37Ra strain of Mtb remains poorly understood. In this study, we utilized RNA-Seq screening, qRT-PCR, and Western Blotting to investigate the differences in these processes between H37Rv and H37Ra infections.
View Article and Find Full Text PDFEl Niño southern oscillation, weather patterns, and bacillary dysentery in the Yangtze River Basin, China.
Glob Health Res Policy
November 2024
Vanke School of Public Health, Tsinghua University, Haidian District, 100084, Beijing, China.
Article Synopsis
- This study explores how climate variability patterns, specifically the El Niño-southern oscillation (ENSO), affect the incidence of bacillary dysentery (BD) in China's Yangtze River Basin from 2005 to 2020.
- Both El Niño and La Niña events were found to raise the risk of BD, with increased regional temperatures and rainfall identified as contributing factors.
- The research highlights the importance of understanding the meteorological pathways influenced by ENSO to improve health responses and develop early warning systems for BD outbreaks.
Treatment of Mycobacterium tuberculosis infected macrophages with Rifabutin loaded β-glucan microparticles induces macroautophagy mediated bacillary killing.
Int J Biol Macromol
December 2024
Department of Life Sciences & Biotechnology, CSJM University, Kanpur 228024, U.P., India. Electronic address:
Tuberculosis (TB), attributable to Mycobacterium tuberculosis (M.tb.), constitutes a formidable global health challenge, particularly with the proliferation of multidrug-resistant (MDR-TB) strains.
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