Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2967/jnumed.122.265056 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Biomarkers.
Alzheimers Dement
December 2024
Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Montréal, QC, Canada.
Background: To evaluate the in vitro binding properties of [C]PiB and [F]NAV4694 head-to-head in post-mortem human brain tissue.
Method: Autoradiography was used to assess uptake of [C]PiB and [F]NAV4694 in control (CN) and Alzheimer's disease (AD) autopsy-confirmed brain tissues. The study focuses on the analysis of the prefrontal cortex, inferior parietal cortex, posterior cingulate cortex and hippocampus sections in 11 CN and 11 AD cases.
Dosimetry Software for Theranostic Applications: Current Capabilities and Future Prospects.
J Nucl Med
January 2025
Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany
Dosimetry is integral to informed implementation of radiopharmaceutical therapies, enabling personalized treatment planning and ensuring patient safety by calculating absorbed doses to organs and tumors. As the therapeutic radiopharmaceutical field continues to expand, dosimetry software has emerged as a crucial tool for optimization of treatment efficacy. This review discusses key features and capabilities that current dosimetry software solutions have or should have in the future.
View Article and Find Full Text PDFDosimetry for Radiopharmaceutical Therapy: Practical Implementation, From the Special Series on Quantitative Imaging.
AJR Am J Roentgenol
January 2025
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY.
Radiopharmaceutical therapy (RPT) is advancing rapidly and achieving wider clinical application. However, RPT is not yet optimized in practice, as tumor and normal-organ dose estimates and, in turn, dose-response relationships remain poorly defined. Internal dosimetry is evolving to address such issues, transitioning from the estimation of population-average organ-level or tumor-level doses to individualized patient-specific sub-organ or sub-tumor doses.
View Article and Find Full Text PDFLocalized In Vivo Prodrug Activation Using Radionuclides.
J Nucl Med
January 2025
Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts;
Radionuclides used for imaging and therapy can show high molecular specificity in the body with appropriate targeting ligands. We hypothesized that local energy delivered by molecularly targeted radionuclides could chemically activate prodrugs at disease sites while avoiding activation in off-target sites of toxicity. As proof of principle, we tested whether this strategy of radionuclide-induced drug engagement for release (RAiDER) could locally deliver combined radiation and chemotherapy to maximize tumor cytotoxicity while minimizing off-target exposure to activated chemotherapy.
View Article and Find Full Text PDFAutomated Measurement of Effective Radiation Dose by F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography.
Tomography
December 2024
Department of Nuclear Medicine and Molecular Imaging, Ajou University School of Medicine, Suwon 16499, Republic of Korea.
Background/objectives: Calculating the radiation dose from CT in F-PET/CT examinations poses a significant challenge. The objective of this study is to develop a deep learning-based automated program that standardizes the measurement of radiation doses.
Methods: The torso CT was segmented into six distinct regions using TotalSegmentator.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!