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Electroencephalographic (EEG) recordings in individuals with Fragile X Syndrome (FXS) and the mouse model of FXS ( KO) display cortical hyperexcitability at rest, as well as deficits in sensory-driven cortical network synchrony. A form of circuit hyperexcitability is observed in cortical slices of KO mice as prolonged persistent activity, or Up, states. It is unknown if the circuit mechanisms that cause prolonged Up states contribute to FXS-relevant EEG phenotypes.
View Article and Find Full Text PDFOptical coherence tomography characteristics in hydroxychloroquine retinopathy and the correlations with visual deterioration in Taiwanese.
Taiwan J Ophthalmol
November 2024
Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
Purpose: This study aimed to investigate optical coherence tomography (OCT) characteristics in hydroxychloroquine (HCQ) retinopathy and their correlation with visual acuity among Taiwanese patients.
Materials And Methods: We retrospectively recruited patients undergoing long-term HCQ treatment who had received examinations of best-corrected visual acuity and OCT scans. We observed disruptions in the ellipsoid zone (EZ) and retinal pigment epithelium (RPE) across different retinal regions.
Genetically Predicted Gut Microbiota Mediate the Association Between Fatty Acids and Intrahepatic Cholestasis of Pregnancy: A Mendelian Randomization Analysis.
Food Sci Nutr
January 2025
Affiliated Women's Hospital of Jiangnan University, Jiangnan University Wuxi China.
Fatty acids (FAs) and gut bacteria likely play vital roles in intrahepatic cholestasis of pregnancy (ICP). However, the causal connection between FAs, gut microbiota, and ICP has not yet been confirmed. To investigate the associations of FAs, gut bacteria, and ICP, a Mendelian randomization (MR) analysis with two samples was performed to identify the potential causal relationships between FAs and ICP.
View Article and Find Full Text PDFThe Role of Morphological Information in Processing Pseudo-words in Italian L2 Learners: It's a Matter of Experience.
J Cogn
January 2025
Department of Humanities, University of Trento, via Tommaso Gar 14, 38122, Trento, Italy.
The productive use of morphological information is considered one of the possible ways in which speakers of a language understand and learn unknown words. In the present study we investigate if, and how, also adult L2 learners exploit morphological information to process unknown words by analyzing the impact of language proficiency in the processing of novel derivations. Italian L2 learners, divided into three proficiency groups, participated in a lexical decision where pseudo-words could embed existing stems (e.
View Article and Find Full Text PDFParkinson's Disease: Current Treatment Modalities and Emerging Therapies.
Cureus
December 2024
Neurology, King Faisal Specialist Hospital and Research Centre, Riyadh, SAU.
Herein, we review the literature on Parkinson's disease (PD) management and summarize the progress in medical, surgical, and assisted therapeutic modalities for motor and non-motor symptoms. A thorough search strategy was implemented to retrieve all relevant articles and identify the best evidence from different databases including Scopus, PubMed, Google Scholar, the Cochrane Database of Systematic Reviews, and Evidence-Based Medicine reviews from the International Parkinson and Movement Disorder Society. Multiple terms, such as Parkinson, tremor, predominant, Parkinson management, deep brain stimulation, LCIG, ablative surgery for PD, medical management of PD, and assistive devices for PD, were used for screening.
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