Noonindoles A-F: Rare Indole Diterpene Amino Acid Conjugates from a Marine-Derived Fungus, CMB-M0339.

Analytical scale chemical/cultivation profiling prioritized the Australian marine-derived fungus CMB-M0339. Subsequent investigation permitted isolation of noonindoles A-F (-) and detection of eight minor analogues (-) as new examples of a rare class of indole diterpene (IDT) amino acid conjugate, indicative of an acyl amino acid transferase capable of incorporating a diverse range of amino acid residues. Structures for - were assigned by detailed spectroscopic and X-ray crystallographic analysis. The metabolites exhibited no antibacterial properties against G-ve and G+ve bacteria or the fungus , with the exception of which exhibited moderate antifungal activity.