AI Article Synopsis
- The study focuses on the silk production process by domesticated silkworms and highlights the role of a specific factor in silk protein synthesis.
- The inhibition or knockout of this factor decreases larval weight and silk yield, impacting the translational rather than transcriptional level of silk protein synthesis.
- RNA sequencing revealed significant differences in amino acid synthesis and metabolism, particularly in glutathione metabolism, leading to reduced levels of essential components for fibroin protein synthesis.
Article Abstract
, domesticated from wild silkworms, is an economic insect that feeds on mulberry leaves and produces silk. In the current study, we demonstrated the contribution of in silk protein synthesis. The inhibition and knockout of can reduce the larva weight and CSW. The effect on CSW of is not on the transcriptional level, but on the translational level. RNA-sequencing data suggested that amino acid synthesis and the metabolism process had a great difference between the and Control strain, particularly glutathione metabolism. An abnormality in glutathione metabolism led to the reduction of free glycine and serine content, which are the main components of fibroin protein. Finally, fibroin protein synthesis has been reduced, including fibroin-heavy chain, fibroin-light chain, and p25 protein. This finding brought to light the role of in the silk protein synthesis process.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696079 | PMC |
| http://dx.doi.org/10.3390/insects13110967 | DOI Listing |
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