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Improvement of ()-selective imine reductase GF3546 for the synthesis of chiral cyclic amines. | LitMetric

Improvement of ()-selective imine reductase GF3546 for the synthesis of chiral cyclic amines.

Chem Commun (Camb)

Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

Published: November 2022

AI Article Synopsis

Article Abstract

An engineered ()-selective imine reductase from sp. GF3546 (SIR46) showed twice the activity of the wild type and high thermostability at 50 °C. Using a biocatalyst based on SIR46, we investigated the activity toward high-concentration 2-methyl-1-pyrroline up to 500 mM, conversion rates of other imines, and reductive amination activity.

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Source
http://dx.doi.org/10.1039/d2cc05116hDOI Listing

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