Objectives: The fact that clinoptilolite reserves are abundant and economical in the world, its toxic effects are not observed in clinical studies in humans and animals, and it has superior physical properties suggests that clinoptilolite may be an easily accessible product for the healing of tooth extraction wounds. The aim of the study was to evaluate the effects of cliniotilolite on bone tissue healing and bone formation in the extraction socket in experimentally diabetic rats by micro-CT analysis.
Materials And Methods: 36 male Wistar Albino rats were divided into 3 main groups as Healthy Control, Diabetes Control and Diabetes + Clinoptilolite. Afterwards, these groups were divided into 2 subgroups to be sacrificed on the 14th and 28th days, and each subgroup had 6 rats (n = 6). At the 14th and 28th days, the rats were sacrificed and the effects of clinoptilolite on bone tissue healing and bone formation in the alveolar socket were evaluated by micro-CT analysis.
Results: According to the statistical analysis results, the difference between the groups in terms of bone volume, bone surface to bone volume, trabecular thickness and hounsfield units values, which are the parameters of the 14th day groups, was statistically significant (p < 0.05). Among the parameters of the 28th day groups, only the hounsfield units value was statistically significant (p < 0.05).
Conclusion: The results of the study show that clinoptilolite can contribute to the healing of extraction wounds and bone formation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638813 | PMC |
| http://dx.doi.org/10.1016/j.jobcr.2022.10.007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Insulinotropic and anti-obesity properties of ethno-medicinal plants: pharmacology-based and predictions.
Nat Prod Res
January 2025
Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, Al-Azhar University (Boys), Cairo, Egypt.
The herbal extracts of four traditional plants; namely leaves, fruits leaves, and seeds, were identified for their main constituents using UHPLC/QTOF-MS/MS. Then, a pharmacology-based analysis and molecular docking verification were established targeting the evaluation of each individual herbal extract for their antidiabetic/anti-obesity potential besides their safety. Streptozotocin-induced diabetic rats were used to evaluate antiobesity and insulinotropic effects against insulin (10 U/Kg, IP) and metformin (100 mg/Kg, per oral) as standard regimens.
View Article and Find Full Text PDFβ-ecdysone/PLGA composite scaffolds promote skull defect healing in diabetic rat.
Front Bioeng Biotechnol
January 2025
Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, College and Hospital of Stomatology, Guangxi Medical University, Nanning, Guangxi, China.
Introduction: Diabetes mellitus often leads to bone metabolism disorders, hindering bone regeneration and delaying the healing of bone defects. β-Ecdysone, a plant-derived hormone known for its wide range of physiological activities, possesses hypoglycemic effects and promotes osteogenic differentiation. This study developed a composite PLGA slow-release scaffold loaded with β-ecdysone to enhance its bioavailability through topical administration and to investigate its potential to heal diabetic bone defects.
View Article and Find Full Text PDFPharmacological modulation of Sigma-1 receptor ameliorates pathological neuroinflammation in rats with diabetic neuropathic pain via the AKT/GSK-3β/NF-κB pathway.
Brain Res Bull
January 2025
Department of Pharmacology, Shaanxi University of Chinese Medicine, Xianyang, 712046, PR China; Key Laboratory of Pharmacodynamic Mechanism and Material Basis of Traditional Chinese Medicine, Shaanxi Administration of Traditional Chinese Medicine, Xianyang 712046, PR China. Electronic address:
Diabetic neuropathic pain (DNP) is a common complication of diabetes mellitus (DM) and is characterized by spontaneous pain and neuroinflammation. The Sigma-1 receptor (Sig-1R) has been proposed as a target for analgesic development. It is an important receptor with anti-inflammatory properties and has been found to regulate DNP.
View Article and Find Full Text PDFImpact of monosodium glutamate-induced obesity on learning, memory, and DNA damage: sex-based comparative study in rats.
Physiol Behav
January 2025
Department of Internal Medicine, Faculty of Medicine, Pamukkale University, Denizli, Türkiye.
Obesity is a global health crisis linked to numerous adverse outcomes including cardiovascular disease, type 2 diabetes, cancer and cognitive decline. This study investigated the sex-specific effects of monosodium glutamate (MSG)-induced obesity on learning, memory, anxiety-like behavior, oxidative stress, and genotoxicity in rats. In 32 neonatal Wistar albino rats, subcutaneous MSG injections were administered to induce obesity.
View Article and Find Full Text PDFRNA-seq reveals Lysyl oxidase as a potential biomarker of glomerular function in diabetic nephropathy in rats.
Gene
January 2025
College of Traditional Chinese Medicine, North China University of Science and Technology, 21 Bohai Road, Tangshan 063210 China. Electronic address:
Purpose: We downloaded the gene expression profiles of patients with diabetic nephropathyfrom the GEO database and combined it with differential gene analysis of rat transcriptome,our study employed animal models to examine the role of key hub genes in diabetic nephropathy and to pinpoint significant gene regulation in this disease.
Methods: An examination of differential expression was performed using the online analysis tool GEO2R and the DN-related datasets GSE30528 and GSE1009 obtained from the GEO database. A comparison of gene expression between the normal and diabetic nephropathy groups was conducted using the RNA-seq technique.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!