Objective: To 1) explore if clinical electrophysiologists with different degrees of experience performing standard nerve conduction studies could run a threshold tracking nerve conduction study (TTNCS) protocol and 2) learn how clinical users view a research-grade TTNCSs neuronal excitability system.
Methods: Five clinical electrophysiologists conducted a TTNCS session using QTracS and then completed a questionnaire describing their impressions.
Results: All of the electrophysiologists completed the QTracS protocol on an initial attempt. Perceived strengths comprised the ease of preparatory steps and quick protocol speed. Identified drawbacks included an unwieldly user-interface. The electrophysiologists indicated that knowledge of TTNCS principles and applications would be critical for incorporation of the method into clinical use.
Conclusions: This pilot study suggests that clinical electrophysiologists can carry out TTNCSs with a research-grade system. The development of a more user-friendly program, along with dedicated education and training, could lead to wider application of the TTNCS technique.
Significance: Considered together with clinical presentation and other biomarkers, increased use of TTNCSs could provide improved assessment of neuromuscular disease and treatment response.
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http://dx.doi.org/10.1016/j.cnp.2022.08.003 | DOI Listing |
J Appl Biomater Funct Mater
March 2025
Kerman Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Peripheral nerve tissue engineering is a field that uses cells, growth factors and biological scaffold material to provide a nutritional and physical support in the repair of nerve injuries. The specific properties of injectable human amniotic membrane-derived hydrogel including growth factors as well as anti-inflammatory and neuroprotective agents make it an ideal tool for nerve tissue repair, and metformin may also aid in nerve regeneration. The aim of this study was to investigate the effects of hydrogel derived from amniotic membrane (AM) along with metformin (MET) administration in the repair of sciatic nerve injury in male rats.
View Article and Find Full Text PDFFront Hum Neurosci
February 2025
Faculty of Electrical Engineering, Automatics and Computer Science, Opole University of Technology, Opole, Poland.
Background: The study includes a correlation analysis of EMG signals of upper limb muscle activity in wheelchair fencers. The aim of the study was to investigate neuromuscular conduction in wheelchair fencers using the EMG signal from their upper limb muscles.
Methods: Wavelet transform analysis was used to examine the biosignals.
Sci Rep
March 2025
Department of Electrical Engineering, Imam Khomeini Naval Science University of Nowshahr, Nowshahr, Iran.
Nerve signal conduction, and particularly in myelinated nerve fibers, is a highly dynamic phenomenon that is affected by various biological and physical factors. The propagation of such moving electric signals may seemingly help elucidate the mechanisms underlying normal and abnormal functioning. This work aims to derive the exact physical wave solutions of the nonlinear partial differential equations with fractional beta-derivatives for the cases of transmission of nerve impulses in coupled nerves.
View Article and Find Full Text PDFACS Sens
March 2025
State Key Laboratory of Electronic Thin Films and Integrated Devices, School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China (UESTC), Chengdu 610054, China.
Hydrogen detection plays a crucial role in various scenes of hydrogen energy such as hydrogen vehicles, hydrogen transportation and hydrogen storage. It is essential to develop a hydrogen detection system with ultrafast response times (<1 s) for the timely detection of hydrogen leaks. Here we report an ultrafast (0.
View Article and Find Full Text PDFMuscle Nerve
March 2025
Department of Neurology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
Introduction/aims: Prolonged distal median motor latency (DML) may occur in carpal tunnel syndrome (CTS), potentially causing an electrodiagnostic dilemma in acquired demyelinating polyneuropathies. We aimed to demonstrate that parameter values obtained from conventional median nerve conduction studies can distinguish immune-mediated demyelination from compression-induced damage.
Methods: We retrospectively reviewed the median nerve records of 73 control individuals, 125 patients with pure CTS, 31 with CTS and diabetic distal symmetric polyneuropathy, 36 with acute inflammatory demyelinating polyneuropathy, and 23 with chronic inflammatory demyelinating polyneuropathy.
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