AI Article Synopsis
- Osteoarthritis affects many middle-aged and elderly individuals, resulting in various issues like unclear causes, poor prognosis, and frequent recurrences that harm both physical and mental health.
- Currently, treatment primarily focuses on symptom relief rather than addressing the underlying causes, highlighting the urgent need for further research.
- This study used protein omics to discover that aging leads to excessive sulfur oxidation in chondrocytes, triggering inflammation and suggesting new pathways for targeted treatments.
Article Abstract
Osteoarthritis, as a common joint disease among middle-aged and elderly people, has many problems, such as diverse pathogenesis, poor prognosis and high recurrence rate, which seriously affects patients' physical and mental health and reduces their quality of life. At present, the pathogenesis of osteoarthritis is not completely clear, and the treatment plan is mainly to relieve symptoms and ensure basic quality of life. Therefore, it is particularly urgent to explore the pathogenesis of osteoarthritis. Protein, as organic macromolecule which plays a major role in life activities, plays an important role in the development of disease. Through protein omics, this study found that with the increase of age, excessive sulfur oxidation occurred in endoplasmic reticulum of chondrocytes, which then drove the occurrence of inflammatory reaction, and provided a direction for the follow-up molecular targeted.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638109 | PMC |
| http://dx.doi.org/10.3389/fphar.2022.1058469 | DOI Listing |
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