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Identification of Relevant Attributes for Liver Cancer Therapies (IRALCT): a maximum-difference-scaling analysis. | LitMetric

AI Article Synopsis

  • The IRALCT project aims to uncover key factors influencing therapy choices for liver cancer, focusing on input from patients, medical laymen, and physicians.
  • By utilizing MaxDiff scaling with 261 participants, the study identified and ranked 14 significant clinical attributes that affect decision-making related to liver cancer treatment.
  • The findings revealed strong alignment in preferences among all three groups regarding the importance of factors like tumor removal certainty, disease recurrence risk, and post-treatment welfare, with a cumulative importance score of 88.3% for the top attributes.

Article Abstract

The Identification of Relevant Attributes for Liver Cancer Therapies (IRALCT) project is intended to provide new insights into the relevant utility attributes regarding therapy choices for malignant primary and secondary liver tumors from the perspective of those who are involved in the decision-making process. It addresses the potential value of taking patients' expectations and preferences into account during the decision-making and, when possible, adapting therapies according to these preferences. Specifically, it is intended to identify the relevant clinical attributes that influence the patients', medical laymen's, and medical professionals' decisions and compare the three groups' preferences. We conducted maximum difference (MaxDiff) scaling among 261 participants (75 physicians, 97 patients with hepatic malignancies, and 89 medical laymen) to rank the importance of 14 attributes previously identified through a literature review. We evaluated the MaxDiff data using count analysis and hierarchical Bayes estimation (HB). Physicians, patients, and medical laymen assessed the same 7 attributes as the most important: probability (certainty) of a complete removal of the tumor, probability of reoccurrence of the disease, pathological evidence of tumor removal, possible complications during the medical intervention, welfare after the medical intervention, duration and intensity of the pain, and degree of difficulty of the medical intervention. The cumulative relative importance of these 7 attributes was 88.3%. Our results show that the physicians', patients', and medical laymen's preferences were very similar and stable.Trial registration DRKS-ID of the study: DRKS00013304, Date of Registration in DRKS: 2017/11/16.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646805PMC
http://dx.doi.org/10.1038/s41598-022-23097-wDOI Listing

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