A 55-year-old woman showed progressive renal dysfunction after unilateral deceased-donor lung transplantation for lymphangioleiomyomatosis. A kidney biopsy showed a striped pattern of interstitial fibrosis, suggesting calcineurin inhibitor toxicity, and zebra body accumulation predominantly in the podocytes, characteristics of Fabry disease. Nevertheless, she had no extra-renal symptoms of the disease, and gene testing identified no known pathogenic variant or exon deletion. Our case report and literature review suggest that this atypical lysosomal inclusion may be phospholipidosis induced by sertraline. Potential underlying etiologies linking zebra body deposits may be not only hereditary but also drug-induced phospholipidosis.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372279PMC
http://dx.doi.org/10.2169/internalmedicine.0882-22DOI Listing

Publication Analysis

Top Keywords

lung transplantation
8
transplantation lymphangioleiomyomatosis
8
zebra body
8
kidney podocyte
4
podocyte zebra
4
zebra bodies
4
bodies lung
4
lymphangioleiomyomatosis 55-year-old
4
55-year-old woman
4
woman progressive
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!