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Background: Left ventricular (LV) remodelling (REM) ensuing after ST-elevation myocardial infarction (STEMI), has typically been studied by echocardiography, which has limitations, or cardiac magnetic resonance (CMR) in early phase that may overestimate infarct size (IS) due to tissue edema and stunning. This prospective, multicenter study investigated LV-REM performing CMR in the subacute phase, and 6 months after STEMI.
Methods And Results: patients with first STEMI undergoing successful primary angioplasty were consecutively enrolled. CMR was done at 30-days and 6-months. Primary endpoint was prevalence at 6 months of LV-REM [≥12% increase in LV end-diastolic volume index (LV-REM)]; LV-REM by end-systolic volume index increase ≥12% (LV-REM) was also calculated. Of 325 patients enrolled, 193 with a full set of research-quality CMR images were analyzed. LV-REM and LV-REM were present in 36/193 (19%) and 34/193 (18%) patients, respectively. At follow up, LV ejection fraction (EF) improved in patients with or without LV-REM, whilst it decreased in those with LV-REM (p < 0.001 for interaction). Considering predictors of LV-REM, IS in the highest tertile was clearly separated from the two lower tertiles. In LV-REM, the highest tertile was associated with significantly higher LV-EDV, LV-ESV, and lower EF.
Conclusions: In a contemporary cohort of STEMI patients studied by CMR, prevalence of LV-REM was lower than previously reported. Importantly, our data indicate that LV-REM might not be "adverse" per se, but rather "compensatory", being associated with LV-EF improvement at follow-up. Conversely, LV-REM might be an "adverse" phenomenon associated with decreased LV-EF, driven by IS.
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http://dx.doi.org/10.1016/j.ijcard.2022.11.006 | DOI Listing |
EClinicalMedicine
January 2025
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, Heidelberg, 69120, Germany.
Background: We aimed to evaluate the incremental predictive value of metabolomic biomarkers for assessing the 10-year risk of type 2 diabetes when added to the clinical Cambridge Diabetes Risk Score (CDRS).
Methods: We utilized 86,232 UK Biobank (UKB) participants (recruited between 13 March 2006 and 1 October 2010) for model derivation and internal validation. Additionally, we included 4383 participants from the German ESTHER cohort (recruited between 1 July 2000 and 30 June 2002 for external validation).
Front Physiol
December 2024
School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China.
Introduction: Automatic segmentation of the left atrium (LA) constitutes a crucial pre-processing step in evaluating heart structure and function during clinical interventions, such as image-guided radiofrequency ablation of atrial fibrillation. Despite prior research on LA segmentation, the low contrast in medical images exacerbates the challenge of distinguishing various tissues, rendering accurate boundary delineation of the target area formidable. Moreover, class imbalance due to the small target size further complicates segmentation.
View Article and Find Full Text PDFPediatr Cardiol
December 2024
Department of Diagnostic Radiology, Tsuchiya General Hospital, 3-30 Nakajima-Cho, Naka-Ku, Hiroshima, 730-8655, Japan.
To evaluate the use of noncontrast-enhanced coronary magnetic resonance angiography (NC-CMRA) for long-term follow-up in patients with Kawasaki disease (KD). In total, 40 (77 aneurysms) patients with KD who underwent NC-CMRA were retrospectively analyzed. Coronary artery aneurysms and dilations observed during the acute phase were classified into three groups according to their diameter based on the American Heart Association criteria.
View Article and Find Full Text PDFMuscle Nerve
December 2024
Division of Pediatric Cardiology, Vanderbilt University Medical Center, Nashville, Tennessee, US.
Introduction/aims: Skeletal muscle magnetic resonance imaging (MRI) is a validated noninvasive tool to assess Duchenne muscular dystrophy (DMD) progression. There is interest in finding DMD biomarkers that decrease the burden of clinical trial participation, such as wearable devices. Our aim was to evaluate the relationship between activity, via accelerometry, and skeletal muscle MRI, particularly T mapping.
View Article and Find Full Text PDFComplement Ther Med
December 2024
Nursing Graduate Program, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil; Department of Nursing, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil. Electronic address:
Objective: This study aims to map the scientific literature on the effects of auriculotherapy in the treatment of anxiety-fatigue and sleep disturbances in cancer patients, highlighting the main application protocols.
Method: A scoping review was conducted following the PRISMA-ScR guidelines and the Joanna Briggs Institute methodology. The search was conducted in twelve data sources by two independent researchers.
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