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| http://dx.doi.org/10.1016/j.celrep.2022.111659 | DOI Listing |
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Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans.
Nat Commun
January 2025
Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Max Planck Institute for Human Development, Berlin, Germany.
During memory formation, the hippocampus is presumed to represent the content of stimuli, but how it does so is unknown. Using computational modelling and human single-neuron recordings, we show that the more precisely hippocampal spiking variability tracks the composite features of each individual stimulus, the better those stimuli are later remembered. We propose that moment-to-moment spiking variability may provide a new window into how the hippocampus constructs memories from the building blocks of our sensory world.
View Article and Find Full Text PDFThe impact of Parkinson's disease on striatal network connectivity and corticostriatal drive: An in silico study.
Netw Neurosci
December 2024
Science for Life Laboratory, Department of Computer Science, KTH Royal Institute of Technology, Stockholm, Sweden.
Striatum, the input stage of the basal ganglia, is important for sensory-motor integration, initiation and selection of behavior, as well as reward learning. Striatum receives glutamatergic inputs from mainly cortex and thalamus. In rodents, the striatal projection neurons (SPNs), giving rise to the direct and the indirect pathway (dSPNs and iSPNs, respectively), account for 95% of the neurons, and the remaining 5% are GABAergic and cholinergic interneurons.
View Article and Find Full Text PDFResearch on Omnidirectional Gait Switching and Attitude Control in Hexapod Robots.
Biomimetics (Basel)
November 2024
School of Electronic and Electrical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China.
To tackle the challenges of poor stability during real-time random gait switching and precise trajectory control for hexapod robots under limited stride and steering conditions, a novel real-time replanning gait switching control strategy based on an omnidirectional gait and fuzzy inference is proposed, along with an attitude control method based on the single-neuron adaptive proportional-integral-derivative (PID). To start, a kinematic model of a hexapod robot was developed through the Denavit-Hartenberg (D-H) kinematics analysis, linking joint movement parameters to the end foot's endpoint pose, which formed the foundation for designing various gaits, including omnidirectional and compound gaits. Incorporating an omnidirectional gait could effectively resolve the challenge of precise trajectory control for the hexapod robot under limited stride and steering conditions.
View Article and Find Full Text PDFMutant huntingtin protein decreases with CAG repeat expansion: implications for therapeutics and bioassays.
Brain Commun
November 2024
Department of Neurodegenerative Disease, Huntington's Disease Centre, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Huntington's disease is an inherited neurodegenerative disorder caused by a CAG repeat expansion that encodes a polyglutamine tract in the huntingtin (HTT) protein. The mutant CAG repeat is unstable and expands in specific brain cells and peripheral tissues throughout life. Genes involved in the DNA mismatch repair pathways, known to act on expansion, have been identified as genetic modifiers; therefore, it is the rate of somatic CAG repeat expansion that drives the age of onset and rate of disease progression.
View Article and Find Full Text PDFSynaptic basis of feature selectivity in hippocampal neurons.
Nature
December 2024
Department of Neuroscience, Columbia University, New York, NY, USA.
A central question in neuroscience is how synaptic plasticity shapes the feature selectivity of neurons in behaving animals. Hippocampal CA1 pyramidal neurons display one of the most striking forms of feature selectivity by forming spatially and contextually selective receptive fields called place fields, which serve as a model for studying the synaptic basis of learning and memory. Various forms of synaptic plasticity have been proposed as cellular substrates for the emergence of place fields.
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