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http://dx.doi.org/10.1002/ejhf.2730 | DOI Listing |
Br J Psychiatry
January 2025
Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong, Australia.
A quirky truth is that the oldest biomarker findings are largely metabolic. These had minimal impact on contemporary thought and research and were largely ignored. They have been rediscovered and validated almost 100 years later, informing our understanding of neurobiology and medical comorbidity and spurring contemporary treatment discovery efforts.
View Article and Find Full Text PDFNutr Rev
September 2024
School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD 4000, Australia.
The translocator protein of 18 kDa (TSPO) and RIM binding protein 1 (RIM-BP1) are both heavily expressed in neurons at the olfactory bulb. These proteins have overlapping functional profiles and are both implicated in the development of obesity. Over 20 years ago, a yeast 2-hybrid experiment discovered that RIM-BP1 interacts with a peptide constructed from a fraction of the TSPO sequence.
View Article and Find Full Text PDFJ Alzheimers Dis Rep
June 2024
Fondazione IRCCS Don Carlo Gnocchi, Milan, Italy.
Crit Rev Oncol Hematol
August 2024
Medical Oncology, Istituto Nazionale Tumori IRCCS "Regina Elena", Rome, Italy. Electronic address:
Several observations indicate that protein expression analysis by immunohistochemistry (IHC) remains relevant in individuals with non-small-cell lung cancer (NSCLC) when considering targeted therapy, as an early step in diagnosis and for therapy selection. Since the advent of next-generation sequencing (NGS), the role of IHC in testing for NSCLC biomarkers has been forgotten or ignored. We discuss how protein-level investigations maintain a critical role in defining sensitivity to lung cancer therapies in oncogene- and non-oncogene-addicted cases and in patients eligible for immunotherapy, suggesting that IHC testing should be reconsidered in clinical practice.
View Article and Find Full Text PDFStud Hist Philos Sci
June 2024
Institut für Philosophie I, Ruhr Universität Bochum, Universitätsstraße 150, Bochum, NRW D-44780, Germany; Facultad de Filosofía y Letras, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (present address), Intendente Güiraldes 2160, Buenos Aires C1428EGA, Argentina. Electronic address:
The historical challenges to bridge the gaps between developmental biology and population or statistical genetics under the explanatory dominance of the Modern Evolutionary Synthesis during the 20th century have been thoroughly documented. However, although several attempts to integrate these fields have been made, most have been deemed unsuccessful. As an example of those efforts, in this paper I discuss the work of James Meadows Rendel, a student of J.
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