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The history of biomarkers in psychiatry: lessons learned, lessons forgotten, lessons rediscovered.

Br J Psychiatry

January 2025

Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong, Australia.

A quirky truth is that the oldest biomarker findings are largely metabolic. These had minimal impact on contemporary thought and research and were largely ignored. They have been rediscovered and validated almost 100 years later, informing our understanding of neurobiology and medical comorbidity and spurring contemporary treatment discovery efforts.

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Rediscovering a Forgotten Link: TSPO and RIM-BP1 in Appetite Regulation.

Nutr Rev

September 2024

School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD 4000, Australia.

The translocator protein of 18 kDa (TSPO) and RIM binding protein 1 (RIM-BP1) are both heavily expressed in neurons at the olfactory bulb. These proteins have overlapping functional profiles and are both implicated in the development of obesity. Over 20 years ago, a yeast 2-hybrid experiment discovered that RIM-BP1 interacts with a peptide constructed from a fraction of the TSPO sequence.

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Article Synopsis
  • Researchers have rediscovered a previously forgotten phenotype of Alzheimer's disease (AD) called presbyophrenia, now referred to as the confabulation-misidentification phenotype.
  • This phenotype is characterized by symptoms similar to Korsakoff syndrome, including severe memory loss, disorientation, confabulation, and additional cognitive impairments.
  • The article summarizes findings about this phenotype and highlights areas that require further investigation to confirm its status as a variant of Alzheimer's disease.
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Rediscovering immunohistochemistry in lung cancer.

Crit Rev Oncol Hematol

August 2024

Medical Oncology, Istituto Nazionale Tumori IRCCS "Regina Elena", Rome, Italy. Electronic address:

Several observations indicate that protein expression analysis by immunohistochemistry (IHC) remains relevant in individuals with non-small-cell lung cancer (NSCLC) when considering targeted therapy, as an early step in diagnosis and for therapy selection. Since the advent of next-generation sequencing (NGS), the role of IHC in testing for NSCLC biomarkers has been forgotten or ignored. We discuss how protein-level investigations maintain a critical role in defining sensitivity to lung cancer therapies in oncogene- and non-oncogene-addicted cases and in patients eligible for immunotherapy, suggesting that IHC testing should be reconsidered in clinical practice.

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A framework for the integration of development and evolution: The forgotten legacy of James Meadows Rendel.

Stud Hist Philos Sci

June 2024

Institut für Philosophie I, Ruhr Universität Bochum, Universitätsstraße 150, Bochum, NRW D-44780, Germany; Facultad de Filosofía y Letras, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (present address), Intendente Güiraldes 2160, Buenos Aires C1428EGA, Argentina. Electronic address:

The historical challenges to bridge the gaps between developmental biology and population or statistical genetics under the explanatory dominance of the Modern Evolutionary Synthesis during the 20th century have been thoroughly documented. However, although several attempts to integrate these fields have been made, most have been deemed unsuccessful. As an example of those efforts, in this paper I discuss the work of James Meadows Rendel, a student of J.

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