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Intratracheal instillation for the testing of pulmonary toxicity in mice-Effects of instillation devices and feed type on inflammation.
Animal Model Exp Med
January 2025
National Research Centre for the Working Environment, Copenhagen, Denmark.
Background: Inhalation exposure is the gold standard when assessing pulmonary toxicity. However, it typically requires substantial amounts of test material. Intratracheal instillation is an alternative administration technique, where the test substance is suspended in a liquid vehicle and deposited into the lung via the trachea.
View Article and Find Full Text PDFBile acids in the lower airways is associated with airway microbiota changes in chronic obstructive pulmonary disease: an observational study.
BMJ Open Respir Res
December 2024
Wal-yan Respiratory Research Centre, The Kids Research Institute Australia, Nedlands, Western Australia, Australia
Background: Chronic obstructive pulmonary disease (COPD) is a complex disorder with a high degree of interindividual variability. Gastrointestinal dysfunction is common in patients with COPD and has been proposed to influence the clinical progression of the disease. Using the presence of bile acid(s) (BA) in bronchoalveolar lavage (BAL) fluid as a marker of gastric aspiration, we evaluated the relationships between BAs, clinical outcomes and bacterial lung colonisation.
View Article and Find Full Text PDFTotal capsulectomy and NPWT for management of a Mycobacterium abscessus breast implant infection unresponsive to antimicrobial therapy: a case report and literature review.
Wounds
November 2024
Department of Plastic, Reconstructive and Aesthetic Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.
Background: Nontuberculous mycobacteria (NTM) periprosthetic infections after breast augmentation procedures are increasingly common worldwide and should raise suspicion after empirical antimicrobial therapy fails but clinical signs of infection persist. In this case experience, the authors suggest the use of negative pressure wound therapy (NPWT) for NTM-infected wounds to obtain a faster periprosthetic space closure, shorten healing time, and anticipate breast reimplantation.
Case Report: This case report describes the successful application of NPWT to manage wound healing after breast removal in a 60-year-old female who underwent secondary breast augmentation 7 years before.
Far Posterior Approach for Rib Fracture Fixation: Surgical Technique and Tips.
JBJS Essent Surg Tech
December 2024
Department of Orthopedics, OhioHealth Health System, Columbus, Ohio.
Article Synopsis
- The video article discusses the far posterior or paraspinal approach for treating posterior rib fractures, which enhances intraoperative visibility and minimizes muscle damage.
- This method helps preserve periscapular strength, achieving up to 95% recovery six months after surgery through muscle-sparing techniques.
- The surgical process involves precise skin incision and careful dissection of muscles like the trapezius, rhomboids, and latissimus dorsi to allow for effective access and treatment of the fractures without significant tissue loss.
Investigating the Use of Novel Blood Processing Methods to Boost the Identification of Biomarkers for Non-Small Cell Lung Cancer: A Proof of Concept.
J Proteome Res
January 2025
Sangui Bio Pty Ltd, Sydney 2065, Australia.
Diagnosis of non-small cell lung cancer (NSCLC) currently relies on imaging; however, these methods are not effective for detecting early stage disease. Investigating blood-based protein biomarkers aims to simplify the diagnostic process and identify disease-associated changes before they can be seen by using imaging techniques. In this study, plasma and frozen whole blood cell pellets from NSCLC patients and healthy controls were processed using both classical and novel techniques to produce a unique set of four sample types from a single blood draw.
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