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Plasma-based proteomic and metabolomic characterization of lung and lymph node metastases in cervical cancer patients.
J Pharm Biomed Anal
January 2025
Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China; Key Laboratory for Molecular Medicine and Chinese Medicine Preparations, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China. Electronic address:
Article Synopsis
- - Metastasis is a major concern in cervical cancer (CC), particularly affecting lymph nodes and lungs, leading to poor patient outcomes and limited predictive tools for determining metastasis risk.
- - The study analyzed plasma samples from CC patients with and without metastasis using advanced proteomics and metabolomics techniques, revealing common inflammatory processes and distinct metabolic changes between lung and lymph node metastasis groups.
- - Researchers identified two promising biomarker panels for predicting lung and lymph node metastasis, demonstrating strong diagnostic potential with high accuracy in both training and testing sets.
Immunodeficiency: Complement disorders.
Allergy Asthma Proc
September 2024
From the Allergy and Immunology Service, Walter Reed National Military Medical Center, Bethesda, Maryland; and.
Article Synopsis
- * Deficiencies or abnormalities in complement proteins can lead to health issues like increased infection risk, autoimmune diseases, and thrombosis, depending on which protein is affected.
- * Diagnosis is done through functional assays to assess overall complement activity and specific factors, while management includes vaccinations, antibiotics, and monitoring for autoimmune conditions.
Complete Description of the Three Pathways of the Complement System in a Series of 430 Patients with Rheumatoid Arthritis.
Int J Mol Sci
July 2024
Division of Rheumatology, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain.
The complement (C) system is implicated in the etiopathogenesis of rheumatoid arthritis (RA). However, there is a lack of studies characterizing all three C pathways in RA patients. This study aimed to evaluate the association between an in-depth examination of the C system and RA patient characteristics, focusing on disease activity and the presence of rheumatoid factor and anti-citrullinated protein autoantibodies (ACPA).
View Article and Find Full Text PDFVisualization and characterization of complement activation in acetylcholine receptor antibody seropositive myasthenia gravis.
Muscle Nerve
October 2024
Department of Medical Sciences, Clinical Neurophysiology, Uppsala University, Uppsala, Sweden.
Introduction/aims: There are no blood biomarkers to monitor treatment effects in myasthenia gravis (MG) or studies visualizing the acetylcholine receptor (AChR) antibody-induced membrane attack complex (MAC) at the human muscle membrane. This study aimed to compare levels of complement activation products and native complement components in MG patients and healthy controls (HCs) and to model the AChR antibody-mediated attacks in human muscle cells.
Methods: We assessed the complement components and activation product levels with enzyme-linked immunosorbent assay and magnetic bead-based sandwich assays in plasma and sera of 23 MG patients and matched HCs.
Understanding the Role of the Complement System in Insulin Resistance and Metabolic Syndrome in Patients With Rheumatoid Arthritis.
J Rheumatol
November 2024
I. Ferraz-Amaro, MD, Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, and Department of Internal Medicine, University of La Laguna (ULL), Tenerife, Spain.
Objective: The complement system has been associated with the etiopathogenesis of rheumatoid arthritis (RA). Insulin resistance (IR) and metabolic syndrome (MetS) are prevalent among patients with RA. The aim of this study was to explore the relationship between a comprehensive evaluation of the complement system and IR, as well as MetS, in patients with RA.
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