Most supply chain and production systems faced multiple manufacturing and delivery challenges during COVID-19 and transformed their supply chain for improved customer service. These challenges are mostly related to stocking and managing the inventory flow throughout the supply chain (from manufacturer to end consumer). Due to the COVID-19 travel and movement restrictions, inventory reorganisation is necessary for fulfilling consumer demand with adequate service facilities. The safety and serviceability of inventory consumption is the primary concern of many retail grocery stores and consumers. Maintaining the supply of groceries items during and post COVID-19 time without disruption is a real operational and policy challenge. Therefore, this research tries to solve an inventory pricing mechanism and retailer's profit under the optimal service level and retailers' promotional efforts. The proposed optimisation model is validated in the grocery retail sector. The grocery retail market situation is modelled when the demand for the grocery product (which may be essential items) and selling price depending on the investment in item promotional effort and consumer serviceability. The retail grocery store's investment in the product promotional efforts, such as awareness of the item availability and no-contact delivery which, may attract consumers. Therefore, the proposed inventory consumption is modelled with an optimisation problem to maximise the store profit with the optimal investment in promotional activities and service facilities to the consumers and maintain an optimal replenishment cycle. The optimisation model is tested with different cases (no investment in promotional efforts, no investment in service facility, and investment in both) of investment to maximise the retailer's profit and stock availability. The optimality results depicted that investment in promotional efforts and service facility givens higher profit to the retailer. The proposed optimisation model's policy implications would help grocery retail store managers to develop operational strategies for maximising profit with the optimal service level and promotional efforts.
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http://dx.doi.org/10.1016/j.jclepro.2022.134784 | DOI Listing |
Introduction: The United States is undergoing a demographic shift with increasing proportions of older adults. Currently, one in three older adults pass away with a form of Alzheimer's disease or related dementias (ADRD). This figure is higher in underrepresented and underserved groups including older adults in rural Appalachian communities.
View Article and Find Full Text PDFBackground: The LatAm-FINGERS trial marks a pioneering initiative as the first non-pharmacological clinical trial encompassing participants from 12 Latin American countries, including Argentina, Brazil, Bolivia, Chile, Colombia, Costa Rica, Ecuador, Dominican Republic, Mexico, Peru, Puerto Rico, and Uruguay. This initiative represents a significant advancement in promoting inclusivity and diversity in clinical trial recruitment, particularly in underserved populations.
Method: The LatAm-FINGERS trial is a multicenter randomized clinical trial evaluating a lifestyle intervention tailored for the Latin American population.
Background: VG-3927 is a highly potent, selective, brain penetrant, oral small molecule TREM2 agonist that is currently under development for the treatment of Alzheimer's disease (AD). TREM2, a receptor expressed on microglia in the brain is critical to microglial function in health and in disease. Among microglia-associated AD risk genes, partial loss-of-function variants of TREM2 confer 2-3 fold increase in risk for developing AD, motivating efforts to identify pharmacological agonists targeting TREM2 as a therapeutic option.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Nairobi, Nairobi, Nairobi, Kenya.
Background: The recruitment of individuals for Alzheimer's disease (AD) genetic studies particularly those with low socioeconomic status, and living in rural areas remains a challenge in Sub-Saharan Africa (SSA), due to stigma-related cultural beliefs that hinder their participation. The Recruitment and Retention of Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD - ADSP) project is a case-control genetic epidemiological study involving individuals who are living with AD and disease - free healthy control individuals. The aim is to build a resource that greatly expands Alzheimer's disease genetic studies in the currently underrepresented African ancestry populations and Hispanic/Latinx individuals.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Background: Asian American, Native Hawaiian, and Pacific Islander (AANHPI) populations are underrepresented in Alzheimer's disease and related dementias (ADRD) research, despite being the fastest growing racial group in the United States. The Collaborative Approach for AANHPI Research and Education (CARE) registry aims to create a sustainable research recruitment source to address this need.
Method: Participants can enroll online, by phone, or in-person by completing an enrollment survey in English, Chinese (Simplified/Traditional), Hindi, Korean, Samoan, or Vietnamese.
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