Thyroid-like follicular carcinoma of the kidney (TLFCK) is a rare cancer that emerged to the medical literature only a few years ago. We present here the first case of thyroid follicular carcinoma-like renal tumor from Syria. The case presented symptomatically and was managed in our surgical unit. Generally, the presenting age described for the previous cases was 19-60 (mean 39.5) with only three cases with younger ages. Here in our case, the patient is only 13 years old making this only the fourth case worldwide of TLFCK in a child. The microscopic view of the tumor showed distinct thyroid features. In addition the immunohistochemical stains played the definitive role in the diagnosis. The staining for Vimentin, and CK19 were diffusively positive. CK7 was focally positive, whereas TTf1, Thyroglobulin, WT1, CD10 and EMA were negative. It is important to consider this diagnosis to spare the patient the treatment protocol of primary thyroid cancer with metastasis.
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http://dx.doi.org/10.1093/jscr/rjac467 | DOI Listing |
Int J Surg Case Rep
January 2025
Vice President Of Education Quality and Scientific Research Council, Al-Sham Private University, Damascus, Syria. Electronic address:
Introduction And Significance: Thyroid-like follicular carcinoma of the kidney is an exceedingly rare neoplasm. Only a few cases have been reported in the literature. This tumor often presents with no specific symptoms and is frequently discovered incidentally during imaging studies.
View Article and Find Full Text PDFVirchows Arch
September 2024
Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Thyroid-like follicular renal cell carcinoma (TLFRCC), an emerging subtype of renal cell carcinoma, presents diagnostic challenges due to its resemblance to normal thyroid tissue. Here, we report a rare case of TLFRCC in a pediatric patient, a demographic rarely affected by this subtype. Histologically resembling a typical TLFRCC, our case exhibited unique features including post-neuroblastoma development, occurrence in a male teenager, and diffuse MelanA expression, which has not been previously reported in TLFRCC.
View Article and Find Full Text PDFFront Oncol
June 2024
Cancer Center, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Cureus
April 2024
Pathology, Shantabaa Medical College and General Hospital, Amreli, IND.
The first categorization for renal tumours was made by the WHO in 1981 and included only renal cell carcinoma (RCC). After that, classification was continuously altered over five decades. The WHO 2022 Classification of Urinary and Male Genital Tumours 2022 (5 edition) is molecular-driven and contains major revisions compared to the earlier classification from 2016.
View Article and Find Full Text PDFClin Nucl Med
April 2024
From the Department of Nuclear Medicine.
Struma ovarii is a rare form of ovarian teratoma composed entirely or mainly of mature thyroid tissue. A 55-year-old woman with persistent hypogastric pain for 4 months was admitted to our hospital. She had undergone resection of struma ovarii 4 years ago.
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