Background: Modern health concerns related to air pollutant exposure in buildings have been exacerbated owing to several factors. Methods for assessing inhalation exposures indoors have been restricted to stationary air pollution measurements, typically assuming steady-state conditions.
Objective: We aimed to examine the feasibility of several proxy methods for estimating inhalation exposure to CO, PM, and PM in simulated office environments.
Methods: In a controlled climate chamber mimicking four different office setups, human participants performed a set of scripted sitting and standing office activities. Three proxy sensing techniques were examined: stationary indoor air quality (IAQ) monitoring, individual monitoring of physiological status by wearable wristband, human presence detection by Passive Infrared (PIR) sensors. A ground-truth of occupancy was obtained from video recordings of network cameras. The results were compared with the concurrent IAQ measurements in the breathing zone of a reference participant by means of multiple linear regression (MLR) analysis with a combination of different input parameters.
Results: Segregating data onto sitting and standing activities could lead to improved accuracy of exposure estimation model for CO and PM by 9-60% during sitting activities, relative to combined activities. Stationary PM and PM monitors positioned at the ceiling-mounted ventilation exhaust in vicinity of the seated reference participant accurately estimated inhalation exposure (adjusted R² = 0.91 and R² = 0.87). Measurement at the front edge of the desk near abdomen showed a moderate accuracy (adjusted R² = 0.58) in estimating exposure to CO. Combining different sensing techniques improved the CO exposure detection by twofold, whereas the improvement for PM exposure detection was small (~10%).
Significance: This study contributes to broadening the knowledge of proxy methods for personal exposure estimation under dynamic occupancy profiles. The study recommendations on optimal monitor combination and placement could help stakeholders better understand spatial air pollutant gradients indoors which can ultimately improve control of IAQ.
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http://dx.doi.org/10.1038/s41370-022-00495-w | DOI Listing |
J Orthop Surg Res
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Central Coast Local Health District, Gosford, NSW, 2295, Australia.
Background: The use of intravenous tranexamic acid (TXA), an antifibrinolytic agent, has been shown to effectively reduce total blood loss and transfusion rates in total knee arthroplasty (TKA). The aim of this paper is to evaluate the implementation lag and clinical uptake of the use of TXA for primary TKA after publication of two landmark studies. Additionally, it assessed the efficacy of TXA use in TKA in reducing post-operative blood transfusions and hospital length of stay (LOS).
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February 2025
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden. Electronic address:
Preoperative estimated glomerular filtration rate is an inexpensive but useful tool in predicting cardiovascular perioperative complications. Estimated glomerular filtration rate, especially considering its interaction with age, might act as a proxy for severity of cardiovascular disease. Further studies regarding the predictive power of estimated glomerular filtration rate to identify patients at risk of perioperative cardiovascular complications are essential.
View Article and Find Full Text PDFBMJ Open
January 2025
Centre for Research in Public Health and Community Care, University of Hertfordshire, Hatfield, UK
Objectives: To assess the feasibility of capturing older care home residents' quality of life (QoL) in digital social care records and the construct validity (hypothesis testing) and internal consistency (Cronbach's alpha) of four QoL measures.
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Pharmacopsychiatry
January 2025
Max Planck Institute of Psychiatry, Munich, Germany.
A subgroup of patients with acute depression show an impaired regulation of the hypothalamic-pituitary-adrenocortical axis, which can be sensitively diagnosed with the combined dexamethasone (dex)/corticotropin releasing hormone (CRH)-test. This neuropathological alteration is assumed to be a result of hyperactive AVP/V1b signalling. Given the complicated procedure of the dex/CRH-test, this study aimed to develop a genetic variants-based alternative approach to predict the outcome of the dex/CRH-test in acute depression.
View Article and Find Full Text PDFInjury
January 2025
Nuffield Department of Orthopaedic, Rheumatology and Musculoskeletal Sciences, University of Oxford. Oxford, United Kingdom.
Introduction: Severe open lower limb fractures are complex and costly injuries. Studies reporting the costs associated with these injuries, the economic impact of complications, and the clinical benefit of adherence to national guidelines have been previously reported. However, the economic benefits of national guidelines and their relationship with length of inpatient stay have not been described.
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