AI Article Synopsis
- Bisphenol A (BPA) is found in both freshwater and marine environments and is known to disrupt endocrine systems, but its long-term toxicity in marine fish, specifically the male marine medaka, has not been fully established.
- In experiments, exposure to BPA led to the development of testis-ova and alterations in male anal fin shapes toward more female characteristics, indicating that anal fin shape is a particularly sensitive indicator of BPA exposure.
- The study also found that BPA exposure decreased the expression of gonadal soma-derived factor (gsdf) and increased liver vitellogenin (vtg) expression in a dose-dependent manner, suggesting these factors could serve as useful biomarkers for assessing the impact of estrogenic endocrine disruptors in
Article Abstract
Bisphenol A (BPA) is an endocrine disruptor that is present in freshwater and marine environments. However, conclusive evidence for the toxicity of chronic BPA exposure to marine fishes remains lacking. Therefore, we investigated the influence of BPA on male marine medaka (Oryzias melastigma). BPA exposure induced formation of testis-ova at 2610 µg/L, and male-type anal fins became more female type in a concentration-dependent manner. Some males with female-type anal fins had normal testes, indicating that anal fin shape is more sensitive to BPA. Gonadal soma-derived factor (gsdf) expression decreased after BPA exposure in the 746 and 2610 µg/L exposure groups, although the changes were not statistically significant. Additionally, liver vitellogenin (vtg) expression increased in a dose-dependent manner and was significantly higher in all exposure groups. vtg and gsdf are likely to be useful biomarkers for the impact of estrogenic endocrine disrupters in O. melastigma.
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| http://dx.doi.org/10.1007/s11356-022-23863-3 | DOI Listing |
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