Prostate cancer clinical outcomes are varied, from non-aggressive asymptomatic to lethal aggressive neuroendocrine forms which represent a critical challenge in the management of the disease. The neurofilament light ( ) is proposed to be a tumor suppressor gene. Studies have shown that expression of the gene is decreased in various cancers. We have used quantitative RT-PCR, immunoblotting, methylation specific PCR, siRNA knockdown followed by migration/invasion assays to determine associations between expression and disease phenotype in a panel of prostate cells. We demonstrate that is overexpressed and it modulates invasion and migration in PC3-ML2 prostate cancers cells which have an aggressive neuroendocrine-like phenotype.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636496 | PMC |
| http://dx.doi.org/10.17912/micropub.biology.000658 | DOI Listing |
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