AI Article Synopsis
- - The study aimed to compare the effectiveness and safety of two methods of administering tranexamic acid (TXA) during total knee arthroplasty (TKA): peri-articular injection (PAI) and intra-articular injection (IAI).
- - A total of six studies involving 491 patients were analyzed, with no significant differences found between the PAI and IAI groups in terms of hemoglobin levels, blood loss, or complications like infections and blood clots.
- - The conclusion suggests that using PAI of TXA is just as effective as utilizing IAI in reducing blood loss after knee surgery.
Article Abstract
Objectives: In this meta-analysis, we aimed to compare the efficacy and safety of peri-articular injection (PAI) and intraarticular injection (IAI) of tranexamic acid (TXA) in total knee arthroplasty (TKA).
Patients And Methods: We performed a comprehensive literature search from electronic databases such as Springer, Web of Science, PubMed, Cochrane Library databases, and ScienceDirect up to October 2021. The language of identified articles was not restricted. The keywords used for the search strategy included: "tranexamic acid", "total knee arthroplasty", "peri-articular injection" and "intra-articular injection".
Results: Two randomized-controlled trials (RCTs) and four non-RCTs with a total of 491 patients met the inclusion criteria. Of the patients, 242 patients were in the PAI group and 249 patients were in the IAI group. No significant difference was observed between the two groups in hemoglobin drop, postoperative drainage volume, total blood loss, blood transfusion requirements, or units of blood transfused. There was no significant difference between the two groups regarding postoperative infection or deep venous thrombosis.
Conclusion: The PAI of TXA is comparable to IAI of TXA in decreasing postoperative blood loss during TKA.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647674 | PMC |
| http://dx.doi.org/10.52312/jdrs.2022.732 | DOI Listing |
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