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A gut-derived hormone suppresses sugar appetite and regulates food choice in Drosophila. | LitMetric

AI Article Synopsis

  • Animals need to adapt their diets to meet nutritional requirements, but how these needs influence food choices is not well understood.
  • Research on female Drosophila (fruit flies) shows that gut cells detect nutrients and release a hormone called neuropeptide F (NPF), which helps regulate appetite.
  • NPF influences food preferences by promoting sugar satiety and encouraging protein-rich food consumption, especially in mated females, highlighting hormonal mechanisms that control dietary choices.

Article Abstract

Animals must adapt their dietary choices to meet their nutritional needs. How these needs are detected and translated into nutrient-specific appetites that drive food-choice behaviours is poorly understood. Here we show that enteroendocrine cells of the adult female Drosophila midgut sense nutrients and in response release neuropeptide F (NPF), which is an ortholog of mammalian neuropeptide Y-family gut-brain hormones. Gut-derived NPF acts on glucagon-like adipokinetic hormone (AKH) signalling to induce sugar satiety and increase consumption of protein-rich food, and on adipose tissue to promote storage of ingested nutrients. Suppression of NPF-mediated gut signalling leads to overconsumption of dietary sugar while simultaneously decreasing intake of protein-rich yeast. Furthermore, gut-derived NPF has a female-specific function in promoting consumption of protein-containing food in mated females. Together, our findings suggest that gut NPF-to-AKH signalling modulates specific appetites and regulates food choice to ensure homeostatic consumption of nutrients, providing insight into the hormonal mechanisms that underlie nutrient-specific hungers.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684077PMC
http://dx.doi.org/10.1038/s42255-022-00672-zDOI Listing

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