AI Article Synopsis

Article Abstract

The long-sought discovery of HER2 as an actionable and highly sensitive therapeutic target was a major breakthrough for the treatment of highly aggressive HER2-positive breast cancer, leading to approval of the first HER2-targeted drug - the monoclonal antibody trastuzumab - almost 25 years ago. Since then, progress has been swift and the impressive clinical activity across multiple trials with monoclonal antibodies, tyrosine kinase inhibitors and antibody-drug conjugates that target HER2 has spawned extensive efforts to develop newer platforms and more targeted therapies. This Review discusses the current standards of care for HER2-positive breast cancer, mechanisms of resistance to HER2-targeted therapy and new therapeutic approaches and agents, including strategies to harness the immune system.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640784PMC
http://dx.doi.org/10.1038/s41573-022-00579-0DOI Listing

Publication Analysis

Top Keywords

her2-positive breast
12
breast cancer
12
targeting her2-positive
4
cancer advances
4
advances future
4
future directions
4
directions long-sought
4
long-sought discovery
4
discovery her2
4
her2 actionable
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!