AI Article Synopsis

  • Epidural spinal cord stimulation (SCS) may enhance limb and autonomic functions, with specific focus on lumbar and thoracic regions for locomotion and blood pressure regulation, respectively.* -
  • The study investigates the use of sacral SCS to stimulate nerves related to the lower urinary tract (LUT) in anesthetized cats, utilizing a high-density electrode array to determine selective activation of LUT nerves.* -
  • Results indicate that sacral SCS can activate pelvic and pudendal nerves, demonstrating the potential for targeted modulation of bladder and urethral function, which could lead to therapeutic applications for individuals with urinary dysfunction due to injury or disease.*

Article Abstract

Epidural spinal cord stimulation (SCS) is a potential intervention to improve limb and autonomic functions, with lumbar stimulation improving locomotion and thoracic stimulation regulating blood pressure. Here, we asked whether sacral SCS could be used to target the lower urinary tract (LUT) and used a high-density epidural electrode array to test whether individual electrodes could selectively recruit LUT nerves.. We placed a high-density epidural SCS array on the dorsal surface of the sacral spinal cord and cauda equina of anesthetized cats and recorded the stimulation-evoked activity from nerve cuffs on the pelvic, pudendal and sciatic nerves.. Here we show that sacral SCS evokes responses in nerves innervating the bladder and urethra and that these nerves can be activated selectively. Sacral SCS always recruited the pelvic and pudendal nerves and selectively recruited both of these nerves in all but one animal. Individual branches of the pudendal nerve were always recruited as well. Electrodes that selectively recruited specific peripheral nerves were spatially clustered on the arrays, suggesting anatomically organized sensory pathways.This selective recruitment demonstrates a mechanism to directly modulate bladder and urethral function through known reflex pathways, which could be used to restore bladder and urethral function after injury or disease.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9855651PMC
http://dx.doi.org/10.1088/1741-2552/aca0c2DOI Listing

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