The ability of D-dimer, albumin, and D-Dimer/albumin ratio to predict in-hospital mortality and intensive care unit admission in COVID-19 patients admitted to the emergency department.

Objectives: COVID-19 can also cause multi-organ failure or severe pneumonia. Therefore, new biomarkers are being investigated for rapid diagnosis, early treatment and reduced mortality rates. In this study, D-dimer and albumin were looked at from a different perspective.

Background: We think that D-dimer/Albumin ratio (DAR), D-dimer and albumin may be parameters that can be used to predict in-hospital mortality and intensive care unit admission in COVID-19 patients.

Methods: The patients included in the study were divided into 2 groups according to their hospitalization status in the service and intensive care unit. These two groups were compared in terms of DAR, other laboratory data and in-hospital mortality.

Results: The primary findings we obtained are as follows: (1) DAR and D-dimer values are higher in patients who died in-hospital, and albumin values are lower than those who survived; (2) D-dimer and DAR median values are significantly higher in the intensive care group than in the service group. Albumin was significantly lower in the intensive care group; (3) D-dimer, albumin and DAR predicting in-hospital mortality, respectively: D-Dimer's sensitivity 56 % and specificity 57 %, albumin's sensitivity 70 % and specificity 53 %, DAR's sensitivity 56 %, specificity is 58 %; (4) The parameter with the highest predictive power for intensive care admission is albumin.

Conclusion: Although albumin had the highest sensitivity values in determining mortality or predicting intensive care admission in our study, we think that D-dimer and DAR may be other parameters to be used to predict intensive care admission and in-hospital mortality (Tab. 5, Fig. 2, Ref. 19) Keywords: COVID-19, albumin, D-dimer, mortality, D-dimer/albumin.