Liquidambarines A - C, three new abietane diterpenoids from Hance and their anti-inflammatory activities.

Liquidambarines A - C (-), three new abietane-type diterpenoids, together with five known compounds (-) were isolated from the resin of Hance. Their structures were elucidated by the combination of spectroscopic and computational methods. We explored their anti-inflammatory potential by analyzing the protein expression of iNOS and COX-2. Compounds and exhibit significant anti-inflammatory activities without cytotoxicity. These experimental studies suggest these new abietane-type diterpenoids have the potential to be candidates for inflammation-associated diseases.