Hydroacylation of alkynes is undoubtedly the simplest and most atom-efficient approach for the synthesis of enones with diverse synthetic applications. Despite significant progress in hydroacylations, no hydroacylations exist that make use of aldehydes without a chelating group, especially when combined with terminal alkynes. Here we report a synergistic nickel-photocatalytic system that allows for the highly regio- and stereoselective hydroacylation of unactivated aldehydes and alkynes in milder conditions without the use of chelating groups.
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