AI Article Synopsis
- The study focused on the protective effects of phycocyanin extract against damage caused by ethanol in male Wistar rats, examining both organ toxicity and cognitive behavior.
- Rats were divided into four groups: a control group, an ethanol group, and two phycocyanin treatment groups receiving different doses, with treatments lasting 14 days.
- Results indicated that phycocyanin significantly reduced the oxidative stress and biochemical changes caused by ethanol, while also improving anxiety levels and exploratory behavior in the rats.
Article Abstract
The aim of this study was to investigate a potential preventive effect of phycocyanin extract from against ethanol- induced hepatorenal toxicity and cognitive behavior impairment in male Wistar rats. The animals were randomly and equally divided into four groups (six animals each): control group received saline solution, ethanol (EtOH) group was injected intraperitoneally with 1 ml/kg of ethanol solution 38% (w/v), phycocyanin groups were treated with 25 (PC1) or 50 (PC2) mg/kg phycocyanin extract followed by ethanol administration. All treatments were conducted for 14 successive days. Results revealed that ethanol induced oxidative stress in brain, liver, and kidney by increasing lipid peroxidation level and SOD and CAT activities. Serum biochemical perturbations were also observed in EtOH group, which was indicated by a significant elevation in ALT, AST, cholesterol, triglycerides, creatinine, and urea levels. Combined exposure to EtOH with phytocyanin contracted these biochemical alterations. Phycocyanin decreased also EtOH-induced anxiety and ameliorated exploratory behavior assessed by the elevated-plus maze and open field tests respectively.
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| http://dx.doi.org/10.1080/01480545.2022.2139843 | DOI Listing |
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