AI Article Synopsis
- About 50% of the susceptibility to atherosclerotic cardiovascular disease (ASCVD) is genetic, with individual genetic variants usually having a small impact on risk.
- Recent studies indicate that combining these genetic variations into polygenic risk scores (PRS) can improve risk assessment compared to traditional factors.
- Current PRS are mainly based on data from individuals of European ancestry, leading to challenges in their effectiveness for non-European populations, particularly in the Asia-Pacific region, which highlights a need for tailored PRS in clinical settings.
Article Abstract
Approximately one-half of the phenotypic susceptibility to atherosclerotic cardiovascular disease (ASCVD) has a genetic basis. Although individual allelic variants generally impart a small effect on risk for ASCVD, an emerging body of data has shown that the aggregation and weighting of many of these genetic variations into "scores" can further discriminate an individual's risk beyond traditional risk factors alone. Consistent with the theory of population genetics, such polygenic risk scores (PRS) appear to be ethnicity specific because their elements comprise single-nucleotide variants that are always ethnicity specific. The currently available PRS are derived predominantly from European ancestry and thus predictably perform less well among non-European participants, a fact that has implications for their use in the Asia-Pacific region. This paper describes the current state of knowledge of PRS, the available data that support their use in this region, and highlights the needs moving forward to safely and effectively implement them in clinical care in the Asia-Pacific region.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9627888 | PMC |
| http://dx.doi.org/10.1016/j.jacasi.2021.08.008 | DOI Listing |
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