A large number of studies suggest that uric acid (UA) is related to the occurrence, complications, and prognosis of atrial fibrillation (AF). However, the guidelines did not clearly elaborate on this issue. The current research results need to be summarized to analyze the association between UA and AF. This study found that in the current clinical research on the relationship between UA and AF, studies mainly focus on the development or complications of AF. A lot of repetitive work does not deepen awareness of this question. In contrast, studies investigating the effects of UA-lowering therapy on the management of AF are limited. The only reports deny the protective effect of UA-lowering therapy. For now, we suggest that UA is close to the occurrence and progression of AF; therefore, it may have important significance as a clinical marker. The role of UA-lowering therapy in the management of AF is one of the next key issues to be explored. It will be a meaningful topic to focus on the latest research on AF ablation and to conduct a secondary analysis to explore the prognostic impact of UA on the latest treatment methods for AF. Multiomics techniques may allow us to have a deeper understanding of the role of UA in AF management in the future.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633180 | PMC |
http://dx.doi.org/10.1155/2022/9355504 | DOI Listing |
Mol Med Rep
March 2025
School of Basic Medicine, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
The incidence of hyperuricemia has increased recently, posing a serious threat to public health. Hyperuricemia is associated with an increased risk of gout, chronic kidney disease (CKD), obesity, metabolic syndrome, type 2 diabetes mellitus, hypertension, hypertriglyceridaemia, metabolic dysfunction‑associated steatotic liver disease, acute kidney injury, coronary heart disease and cardiovascular disease (CVD). These diseases are commonly accompanied by varying degrees of kidney damage.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
College of Food Science and Technology, Bohai University, National & Local Joint Engineering Research Center of Storage, Processing and Safety Control Technology for Fresh Agricultural and Aquatic Products, China Light Industry Key Laboratory of Marine Fish Processing, Jinzhou, Liaoning 121013, China.
Food Funct
December 2024
Ningbo Innovation Center, Zhejiang University, Ningbo 315000, China.
Mulberry () is a traditional Chinese fruit that has beneficial effects due to its numerous biological activities. This study aimed to investigate the anti-hyperuricemic activity and underlying mechanism of laboratory-prepared mulberry water extract in mice with hyperuricemia (HUA). Additionally, the effect of mulberry extract (ME) on the microbiota was investigated.
View Article and Find Full Text PDFSheng Wu Gong Cheng Xue Bao
November 2024
Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100071, China.
Int Immunopharmacol
December 2024
Nephrosis Precision Medicine Innovation Center, Beihua University School of Basic Medical Science, Jilin 132011, Jilin, China; Jilin Province Science and Technology Innovation Center of Kidney Disease Precision Medicine Based on Gene Sequencing, Beihua University, Jilin 132011, Jilin, China. Electronic address:
Hyperuricemia is a known risk factor for chronic kidney disease (CKD) and subsequent renal fibrosis. N6-methyladenosine (m6A) is the most prevalent chemical modification in eukaryotic mRNAs and has been implicated in various diseases. However, its role in hyperuricemic nephropathy (HN) remains unclear.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!