New insights in addressing cerebral small vessel disease: Associated with extracellular fluid in white matter.

Objective: To explore the role of extracellular fluid, assessed by diffusion tensor imaging (DTI) metrics of free water (FW), in the white matter of patients with cerebral small vessel disease (CSVD).

Materials And Methods: The baseline clinical and imaging data of 129 patients with CSVD were collected and reviewed. CSVD MR markers, including periventricular white matter hyperintensity (PWMH), deep white matter hyperintensity (DWMH), cerebral microbleed (CMB), enlarged perivascular space (PVS), and lacunar infarction (LI), were identified, and CSVD burden was calculated. According to total CSVD MR marker score, cases were classified as mild, moderate, or severe. The mean FW and fractional anisotropy (FA) values were calculated using DTI images.

Results: The mean white matter FW was associated with the CSVD MR markers, including PWMH, DWMH, LI and PVS ( < 0.05). Moreover, age, hypertension, diabetes mellitus, and FW value were associated with total CSVD MR marker score ( < 0.05). Ordinal logistic regression analysis revealed that FW and age were independently associated with CSVD burden ( < 0.05). Finally, FW in white matter was associated with FA (r = -0.334, P < 0.001).

Conclusion: Extracellular fluid changes, assessed by DTI metrics of FW in white matter, were associated with CSVD markers and burden. An increased extracellular fluid volume in the white matter was associated with lower FA.