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Chronic experimental autoimmune encephalomyelitis is an excellent model to study neuroaxonal degeneration in multiple sclerosis. | LitMetric

Chronic experimental autoimmune encephalomyelitis is an excellent model to study neuroaxonal degeneration in multiple sclerosis.

Front Mol Neurosci

UCLA MS Program, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.

Published: October 2022

AI Article Synopsis

  • Animal models of multiple sclerosis, particularly the experimental autoimmune encephalomyelitis (EAE) model, are key for developing anti-inflammatory treatments for MS.
  • The chronic EAE model in C57BL/6 mice, induced by myelin oligodendrocyte glycoprotein (MOG) peptide 35-55, shows similar neuropathological features to MS, including white matter lesions and widespread damage in various brain regions.
  • This review suggests that the chronic EAE model is an effective tool for studying neuroaxonal degeneration associated with multiple sclerosis.

Article Abstract

Animal models of multiple sclerosis (MS), specifically experimental autoimmune encephalomyelitis (EAE), have been used extensively to develop anti-inflammatory treatments. However, the similarity between MS and one particular EAE model does not end at inflammation. MS and chronic EAE induced in C57BL/6 mice using myelin oligodendrocyte glycoprotein (MOG) peptide 35-55 share many neuropathologies. Beyond both having white matter lesions in spinal cord, both also have widespread neuropathology in the cerebral cortex, hippocampus, thalamus, striatum, cerebellum, and retina/optic nerve. In this review, we compare neuropathologies in each of these structures in MS with chronic EAE in C57BL/6 mice, and find evidence that this EAE model is well suited to study neuroaxonal degeneration in MS.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629273PMC
http://dx.doi.org/10.3389/fnmol.2022.1024058DOI Listing

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