A method to obtain tetrahydroisoquinolines (THIQs) fused to tetrahydrofuran rings from aminosugar derivatives has been developed. The procedure relies on a key deprotection of benzyl ethers followed by a double-cyclization sequence, using FeCl as the sole reagent. This tandem reaction affords the construction of novel fused polycyclic heterocycles with total stereochemical control.
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| http://dx.doi.org/10.1021/acsomega.2c04804 | DOI Listing |
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