Polymicrobial lung empyema.

is a well-known cause of enteritis and antibiotic-associated diarrhea. Extraintestinal infection is uncommon, with most extraintestinal infections involving the intra-abdominal cavity and anatomic structures adjacent to the colon. Empyema secondary to is especially rare, with only a handful of cases reported in the medical literature. A standard antibiotic treatment regimen for empyema does not currently exist, and data chronicling successful treatment is limited. We present the case of an 80-year-old woman with a polymicrobial empyema who was successfully treated with multiple chest tube insertions and intravenous vancomycin.