A previously developed abomasal infusion device was modified for easy and successful placement of infusion lines into the abomasum of dairy cows. Similar to the original device, the modified device consists of 2 pieces: an insertion tool and a delivery tool. Updates include streamlining both the insertion and delivery tools by slightly altering dimensions and design, then smoothing all rough edges. The primary changes include a parallel cut along the entire length of the insertion and delivery tools and encasement of the infusion line inside both tools, allowing for smoother insertion through the reticulum-omasum orifice and into the omasum and abomasum. Additionally, increasing the outside diameter of the delivery tool to reduce the gap between the delivery tool and insertion tool, increasing the length of the tools, and making a loop of cord attached to the insertion tool facilitate insertion and easy ejection of the flange into the abomasum. By using this modified device, placement of abomasal infusion lines (including flange) was more successful.
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http://dx.doi.org/10.3168/jdsc.2021-0201 | DOI Listing |
ACS Nano
January 2025
Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China.
For idiopathic pulmonary fibrosis (IPF), interleukin 11 (IL-11) is a pivotal cytokine that stimulates the transformation of fibroblasts into myofibroblasts, thus accelerating the progression of pulmonary fibrosis. Here, we develop an innovative inhalable small interfering RNA (siRNA) delivery system termed PEI-GBZA, which demonstrates impressive efficiency in loading siIL-11 targeting IL-11 (siIL-11) and substantially suppresses the differentiation of fibroblasts into myofibroblasts and epithelial-mesenchymal transition (EMT), reduces neutrophil and macrophage recruitment, and ultimately relieves the established fibrotic lesions in the IPF model. PEI-GBZA is prepared by modifying low-molecular-weight polyethylenimine (PEI) with 4-guanidinobenzoic acid (GBZA).
View Article and Find Full Text PDFJ Craniofac Surg
January 2025
Department of Craniomaxillofacial Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Objective: Finite element analysis (FEA) of the biomechanical properties of the modified extraoral distractor device used in the mandibular distraction of craniofacial microsomia patients.
Materials And Methods: Finite element analysis (FEA) models of 5 patients under 2 working conditions, the instance when the distractor is activated and when the distractor participates in mastication, were included in the current study. To conduct the FEA, load boundary conditions (35.
Elife
January 2025
Department of Biology, Technion - Israel Institute of Technology, Haifa, Israel.
Dendrites are crucial for receiving information into neurons. Sensory experience affects the structure of these tree-like neurites, which, it is assumed, modifies neuronal function, yet the evidence is scarce, and the mechanisms are unknown. To study whether sensory experience affects dendritic morphology, we use the arborized nociceptor PVD neurons, under natural mechanical stimulation induced by physical contacts between individuals.
View Article and Find Full Text PDFAdv Mater
January 2025
Institute of Thin Film Physics and Applications, Shenzhen Key Laboratory of Advanced Thin Films and Applications, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, State Key Laboratory of Radio Frequency Heterogeneous Integration, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China.
Anisotropic carrier transport and deep-level defect of antimony selenosulfide (Sb(S,Se)) absorber are two vital auses restraining the photovoltaic performance of this emerging thin-film solar cell. Herein, chelate engineering is proposed to prepare high-quality Sb(S,Se) film based on hydrothermal deposition approach, which realizes desirable carrier transport and passivated defects by using tetrahedral PO ion in dibasic sodium phosphate (NaHPO, DSP). The PO Lewis structure, on one hand in the form of [(SbO)(PO)] chelate, can adsorb on the polar planes of cadmium sulfide (CdS) layer, promoting the heterogeneous nucleation, and on the other hand, the tetrahedral PO inhibits horizontal growth of (SbS(e)) ribbons due to size effects, thus achieving desirable [hk1] orientation.
View Article and Find Full Text PDFJ Family Med Prim Care
December 2024
Department of Neonatology, All India Institute of Medical Science, Jodhpur, Rajasthan, India.
Context: Heart rate (HR) is the most vital parameter to assess hemodynamic transition at birth. ECG is considered a gold standard for HR assessment. New devices with dry electrodes are easy to apply on a wet newborn.
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