Patients with established coronary artery disease remain at elevated risk of major adverse cardiac events. The goal of this study was to evaluate the utility of plasminogen activator inhibitor-1-positive platelet-derived extracellular vesicles as a biomarker for major adverse cardiac events and to explore potential underlying mechanisms. Our study suggests these extracellular vesicles as a potential biomarker to identify and a therapeutic target to ameliorate neointimal formation of high-risk patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626902 | PMC |
| http://dx.doi.org/10.1016/j.jacbts.2022.05.002 | DOI Listing |
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