AI Article Synopsis
- West Nile virus neuroinvasive disease (WNV-NID) is hard to diagnose, but procalcitonin (PCT) levels can help distinguish it from bacterial infections.
- In a case series, four patients with WNV-NID showed low PCT values, indicating a lack of bacterial co-infections.
- This study suggests that low serum PCT levels could be a reliable indicator for diagnosing WNV-NID.
Article Abstract
Unlabelled: West Nile virus neuroinvasive disease (WNV-NID) is challenging to diagnose. Procalcitonin (PCT) is a useful diagnostic test to identify bacterial infections. We present four cases of WNV-NID with serum PCT measurements.
Methods: Daily (days 1-7) serum PCT (bioMérieux) was examined for critically ill patients with sepsis enrolled in a provincial sepsis study. Patients with identified WNV-NID are descriptively analyzed in this case series. PCT values of ≥0.5 ng/mL were suggestive of bacterial infection.
Results: Four patients with WNV-NID were identified. Those with viral infections alone had consistently low PCT values ranging from 0.09 ng/mL to 0.34 ng/mL. Those with documented bacterial co-infections had initially elevated PCT levels that decreased by more than 50% with antimicrobial therapy.
Conclusion: These cases are the first to report serial PCT measurements in confirmed cases of WNV-NID and support a low serum PCT in WNV-NID.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9615461 | PMC |
| http://dx.doi.org/10.3138/jammi-2020-0046 | DOI Listing |
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