Background: Post dural puncture headache (PDPH) delays discharge from hospital. We studied the efficacy of sphenopalatine ganglion (SPG) block, a novel technique in management of PDPH using 0.25% Ropivacaine.
Methodology: Forty patients presenting with PDPH after urological procedures under spinal anaesthesia were randomized into two groups: Group C and Group S. Group C received conservative treatment with bed rest, adequate hydration and caffeine 200 mg 6 hourly. Group S patients received SPG block (packing bilateral nostril for 10 minutes with 0.25% Ropivacaine). Inj Paracetamol 1 g IV was given as primary analgesic. Intravenous Diclofenac 75 mg was administered as rescue analgesic. Patients were monitored for 72 hours. Total analgesic requirement, time to attain adequate pain relief, headache pain score, patient satisfactory score were compared between the two groups. We compared the PDPH severity score for headache using 5-point scale method and patient satisfaction score using Likert-type scale.
Results: Demographic data, onset of PDPH, needle size, intervention time were statistically insignificant. Total paracetamol consumption was significantly reduced in SPG group. Headache pain score was significantly low in Group S up to 54 hours. Patient satisfaction score was statistically better in Group S. Mean block onset time was 12 minutes. One patient in Group C required Epidural blood patch.
Conclusion: SPG block is an effective alternative in managing patients with PDPH. The need for epidural blood patch is greatly reduced using SPG block. Procedural safety, immediate and sustained pain relief make it an evolving treatment modality for PDPH.
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http://dx.doi.org/10.4103/sja.sja_780_21 | DOI Listing |
ACS Appl Mater Interfaces
January 2025
Department of Chemical System Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan.
Polyethylene glycol (PEG)-coated microsized artificial oxygen carriers (AOCs) with a perfluorooctyl bromide (PFOB) core and poly(lactide--caprolactone) (PLC) shell were successfully fabricated using Shirasu porous glass (SPG) membrane emulsification. The PEG coating was achieved by adding the polylactide--polyethylene glycol--polylactide (PLA-PEG-PLA) block copolymer to the disperse phase during the SPG membrane emulsification process. During the DCM evaporation process, the three-layer structure of the PEG layer, PLC shell, and PFOB core of the AOCs spontaneously formed by phase separation.
View Article and Find Full Text PDFDiabetes Metab J
November 2024
Department of Urology, Affiliated Hospital of Guizhou Medical University, Clinical Medical College of Guizhou Medical University, Guiyang, China.
Background: Diabetes-induced testicular damage (DITD) is a common complication of diabetes. We investigated underlying mechanism of retinoblastoma-binding protein 6 (Rbbp6)-mediated brain and muscle ARNT-like 1 (Bmal1) ubiquitination in modulating ferroptosis in DITD.
Methods: Spermatogenic cell apoptosis and viability were measured by flow cytometry and cell counting kit 8 (CCK-8), respectively.
Angew Chem Int Ed Engl
October 2024
Department of Chemistry, Khalifa University of Science & Technology, Abu Dhabi, P.O. Box 127788, UAE.
Tuning the charge density at the active site to balance the adsorption ability and reactivity of oxygen is extremely significant for driving a two-electron oxygen reduction reaction (ORR) to produce hydrogen peroxide (HO). Herein, we have highlighted the influence of intermolecular polarity in covalent organic frameworks (COFs) on the efficiency and selectivity of electrochemical HO production. Different C3 symmetric building blocks have been utilized to regulate the charge density at the active sites.
View Article and Find Full Text PDFCereb Cortex
September 2024
BCBL, Basque Center on Cognition, Brain and Language, Mikeletegi Pasalekua 69, Donostia 20009, Spain.
As a logographic writing system, Chinese reading involves the processing of visuospatial orthographic (ORT) properties. However, this aspect has received relatively less attention in neuroimaging research, which has tended to emphasize phonological (PHO) and semantic (SEM) aspects in processing Chinese characters. Here, we compared the functional correlates supporting all these three processes in a functional MRI single-character reading study, in which 35 native Chinese adults were asked to make ORT, PHO, and SEM judgments in separate task-specific activation blocks.
View Article and Find Full Text PDFCephalalgia
August 2024
Department of Neuromedicine and Movement Science, NTNU Norwegian University of Science and Technology, Trondheim, Norway.
Background: A novel technique for injection of OnabotulinumtoxinA (BTA) towards the sphenopalatine ganglion (SPG) has shown promise in refractory chronic migraine (CM) and chronic cluster headache (CCH). Open label safety and efficacy data are presented here.
Methods: Patients with refractory CM or CCH who had received at least one injection and completed headache diaries were included.
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