A pair of new quinolone alkaloid enantiomers, ()-(-)-viridicatol () and ()-(+)-viridicatol (), and seven known compounds, namely, , and -, were isolated from SD.84. The structures of and were determined using NMR and HRESIMS data. Theoretical calculations through CD and ECD confirmed and as a pair of enantiomers. The MIC values of against and methicillin-resistant were 12.4 and 24.7 μM, respectively, compound had no inhibitory activity. Antimicrobial assays of , , and - showed a moderate activity against and methicillin-resistant . This study demonstrated the remarkable potential of sp. to produce new drug-resistant leading compounds, thereby advancing the mining for new sources of antimicrobial agents.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1080/14786419.2022.2140150 | DOI Listing |
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!