AI Article Synopsis
- - The study investigates whether beta-blockers (BBs) can reduce the risk of aortic dilation in patients with giant-cell arteritis (GCA) and aortitis, analyzing data from 65 patients.
- - Results show that 23% of the participants were on BBs, and none of these patients experienced new aortic dilation, while 30% of those not on BBs did, suggesting BBs may have a protective effect.
- - The authors conclude that BBs, alongside standard treatment, might help prevent aortic dilation in GCA-related aortitis, but emphasize the need for larger studies to validate these findings.
Article Abstract
Objectives: To analyze whether beta-blockers (BBs), in addition to conventional care, can decrease the risk of aortic dilation in giant-cell arteritis (GCA)-related aortitis.
Methods: We conducted in a single medical center retrospective study including 65 consecutive patients with GCA-related aortitis who all underwent aortic morphology control during follow-up. The impact of previous cardiovascular (CV) risk factors and/or events on BB prescription and on the risk for new aortic dilation was analyzed using a weighted (8-point maximum) score between 0 (i.e., 0/8 CV risk factors and events) and 1 (i.e., 8/8).
Results: Among the 65 patients with GCA-related aortitis, 15 (23%) were taking BBs before GCA diagnosis and continued them thereafter. The vascular score was significantly higher in patients who received BBs (0.25 [0.125-0.625] vs. 0.125 [0-0.625] in patients without BBs, p < 0.0001). The median follow-up was 91 [25-163] months in GCA patients taking BBs and 61 [14-248] months in patients not taking BBs (p = 0.13). None of the patients taking BBs developed a new aortic dilation, whereas 15 (15/50; 30%) patients not taking BBs did (p = 0.01), as detected at a median time of 38 [6-120] months after the first imaging. Rates of other CV events during follow-up did not differ between the groups (p = 1).
Conclusions: This study is the first to suggest that BBs in addition to conventional care in patients with GCA-related aortitis may help to prevent the risk of aortic dilation during follow-up. Larger-sized studies are required to confirm these results.
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| http://dx.doi.org/10.1016/j.semarthrit.2022.152117 | DOI Listing |
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