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Microwave dielectric properties of normal, fibroelastotic, and malignant human lung tissue.
Biomed Phys Eng Express
August 2024
Department of Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI 53706, United States of America.
Technological development of microwave treatment and detection techniques for lung cancer requires accurate and comprehensive knowledge of the microwave dielectric properties of human lung tissue. We characterize the dielectric properties of room temperature human lung tissue from 0.5 to 10 GHz for three lung tissue groups: normal, fibroelastotic, and malignant.
View Article and Find Full Text PDFMicrowave-induced thermoacoustic signal characteristics in a dynamic temperature environment.
Biomed Phys Eng Express
April 2022
Department of Electrical and Computer Engineering, University of Wisconsin-Madison, 1415 Engineering Drive, Madison, WI 53706 United States of America.
We conduct a simulation-based study to investigate the impact of a dynamic temperature environment on the characteristics of microwave-induced thermoacoustic signals. We investigate thermoacoustic signals that are generated using an interstitial microwave ablation antenna powered by a microsecond pulsed microwave source. Two temperature regimes are examined: first, a spatially uniform temperature throughout the medium to experimentally validate the simulation model, and second, the realistic, spatially nonuniform temperature profiles that arise during microwave ablation.
View Article and Find Full Text PDFMulti-physics modeling of thermoacoustic pulse generation and propagation during pulsed microwave ablation of tissue.
Annu Int Conf IEEE Eng Med Biol Soc
July 2020
Microwave-induced thermoacoustic (TA) imaging is a potential alternative to conventional real-time imaging methods for monitoring microwave ablation (MWA). In this study, we develop a multi-physics model for the generation and propagation of microwave-induced TA signals during pulsed MWA. Our model couples electromagnetics, heat transfer, and acoustics physics.
View Article and Find Full Text PDFOutcome of patients with Stage II/favorable histology Wilms tumor with and without local tumor spill: a report from the National Wilms Tumor Study Group.
Pediatr Blood Cancer
January 2014
Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee.
Background: Intra-operative tumor spill increases the risk of local recurrence of Wilms tumor, and adversely impacts relapse-free (RFS) and overall survival (OS) rates.
Methods: Surgical checklists, operative notes, institutional pathology reports, central pathology review and flow sheets of 602 patients registered between August 1986 and September 1994 on National Wilms Tumor Study-4 as randomized, followed or switched and coded as Final Stage II, favorable histology (FH) were reviewed. RFS and OS were estimated using the Kaplan-Meier method.
AZ64 inhibits TrkB and enhances the efficacy of chemotherapy and local radiation in neuroblastoma xenografts.
Cancer Chemother Pharmacol
September 2012
Division of Oncology, Children's Hospital of Philadelphia, PA 19104-4302, USA.
Neuroblastoma is a common pediatric tumor characterized by clinical heterogeneity. Because it is derived from sympathetic neuroblasts, the NTRK family of neurotrophin receptors plays an integral role in neuroblastoma cell survival, growth, and differentiation. Indeed, high expression of NTRK1 is associated with favorable clinical features and outcome, whereas expression of NTRK2 and its ligand, brain-derived neurotrophic factor (BDNF), are associated with unfavorable features and outcome.
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