CNTF induces Clcf1 in astrocytes to promote the differentiation of oligodendrocyte precursor cells.

Biochem Biophys Res Commun

Ningxia Medical University, Yinchuan, 750004, China; Department of Neurosurgery, Huazhong University of Science and Technology Union Shenzhen Hospital, The Sixth Affiliated Hospital of Shenzhen University, Shenzhen, 518000, China. Electronic address:

Published: December 2022

AI Article Synopsis

  • - Neural stem cells (NSCs) are crucial for regeneration in the central nervous system but face challenges because of a harsh microenvironment, limiting their effectiveness in therapies.
  • - Research indicates that NSCs engineered to overexpress ciliary neurotrophic factor (CNTF) show improved remyelination effects, but the exact mechanism is not fully understood.
  • - The study reveals that CNTF-NSCs can induce astrocytes to produce cardiotrophin-like cytokine 1 (Clcf1), which promotes the differentiation of oligodendrocyte precursor cells, highlighting Clcf1 as a potential therapeutic target for demyelinating diseases.

Article Abstract

NSCs play an essential role in the regeneration process of the central nervous system. However, due to the influence of the harsh pathological microenvironment, the viability of neural stem cells is limited, and the therapeutic effect needs improvement. Previous studies have found that stem cells overexpressing ciliary neurotrophic factor (CNTF) have apparent therapeutic effects on remyelination, but the specific mechanism of action still needs to be further explored. We found that astrocytes, the most numerous groups in the CNS, exhibited a pathological role in the experimental autoimmune encephalomyelitis model, but after stimulation with CNTF-NSCs, a phenotypic switch occurred and induced the neurotrophic factor cardiotrophin-like cytokine 1 (Clcf1) production. Mechanistically, Clcf1 can significantly promote the differentiation of oligodendrocyte precursor cells (OPCs), and the advanced effect can attenuate by the Clcf1 antibody. Therefore, this study was conducted to investigate the pathway by which CNTF-NSCs exert their therapeutic effects by affecting astrocytes. It is expected to identify a potential therapeutic factor, Clcf1, for the treatment of demyelinating diseases.

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Source
http://dx.doi.org/10.1016/j.bbrc.2022.10.013DOI Listing

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