In the developing mammalian testis, only a small proportion of fetal and neonatal prospermatogonia give rise to the foundational pool of spermatogonial stem cells (SSCs). Multiple lines of evidence have suggested the determination of which prospermatogonia give rise to foundational SSCs is not random, but is rather predetermined, such that foundational SSCs are ensured to develop advantageous characteristics such as enhanced genetic integrity. Here I suggest that differential epigenetic programing contributes to the molecular mechanisms by which an early subset of developing prospermatogonia becomes predetermined to form the foundational pool of SSCs. This would include epigenetic programing that promotes active expression of genes needed to develop advantageous characteristics, as well as differential epigenetic priming, which bookmarks genes that comprise the SSC-specific transcriptome to become activated when foundational SSCs appear in the postnatal testis. I suggest that, together, differential epigenetic programing and epigenetic priming contribute to the molecular mechanisms by which an early subset of developing prospermatogonia becomes predetermined to form the foundational pool of SSCs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/andr.13332 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Copper-Induced Transgenerational Plasticity in Plant Defence Boosts Aphid Fitness.
Plant Cell Environ
January 2025
Institute of Organismic and Molecular Evolution, University of Mainz, Mainz, Rheinland-Pfalz, Germany.
Transgenerational plasticity in plants is an increasingly recognized phenomenon, yet it is mostly unclear whether transgenerational plasticity is relevant to both the fitness of the plant and its interacting species. Using monoclonal strains of the giant duckweed (Spirodela polyrhiza) and its native herbivore, the waterlily aphid (Rhopalosiphum nymphaeae), we assessed whether pre-treating plants with copper excess, both indoors and outdoors, induces transgenerational plasticity in plant defences that alter plant and herbivore fitness. Outdoors, copper pre-treatment tended to increase plant growth rates under recurring copper excess.
View Article and Find Full Text PDFThe potential for heat shock exposure during early development to alter the molecular responses to subsequent exposure to heat stress in the rainbow trout.
Comp Biochem Physiol A Mol Integr Physiol
January 2025
Biosciences, College of Life & Environmental Sciences, University of Exeter, UK; Centre for Sustainable Aquaculture Futures, University of Exeter, Exeter, UK.
Fish are ectothermic animals with temperature playing a key role in their health, growth and survival. Greater occurrence of heat waves and temperature extremes, as a result of global climate change, has the potential to impact both wild and farmed populations. Within aquaculture, production is threatened by a multitude of stressors, including adverse temperatures.
View Article and Find Full Text PDFTRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states.
Nat Cancer
January 2025
Department of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.
Mutations in cancer risk genes increase susceptibility, but not all carriers develop cancer. Indeed, while DNA mutations are necessary drivers of cancer, only a small subset of mutated cells go on to cause the disease. To date, the mechanisms underlying individual cancer susceptibility remain unclear.
View Article and Find Full Text PDFIntegrative proteogenomic analysis identifies COL6A3-derived endotrophin as a mediator of the effect of obesity on coronary artery disease.
Nat Genet
January 2025
Department of Human Genetics, McGill University, Montréal, Québec, Canada.
Obesity strongly increases the risk of cardiometabolic diseases, yet the underlying mediators of this relationship are not fully understood. Given that obesity strongly influences circulating protein levels, we investigated proteins mediating the effects of obesity on coronary artery disease, stroke and type 2 diabetes. By integrating two-step proteome-wide Mendelian randomization, colocalization, epigenomics and single-cell RNA sequencing, we identified five mediators and prioritized collagen type VI α3 (COL6A3).
View Article and Find Full Text PDFMacrophage Polarisation in the Tumour Microenvironment: Recent Research Advances and Therapeutic Potential of Different Macrophage Reprogramming.
Cancer Control
January 2025
Department of Thoracic Surgery, Affiliated Hospital 6 of Nantong University, Medical School of Nantong University, Nantong, PR China.
Background: Macrophages are a critical component of the innate immune system, derived from monocytes, with significant roles in anti-inflammatory and anti-tumour activities. In the tumour microenvironment, however, macrophages are often reprogrammed into tumour-associated macrophages (TAMs), which promote tumour growth, metastasis, and therapeutic resistance.
Purpose: To review recent advancements in the understanding of macrophage polarisation and reprogramming, highlighting their role in tumour progression and potential as therapeutic targets.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!