AI Article Synopsis
- The study investigates kidney transplant outcomes comparing donors after controlled cardiac death (cDCD) and expanded criteria brain death (DBD-EC) donors to address donor shortages.
- It analyzes data from 129 cDCD and 166 DBD-EC kidney transplant recipients over a median follow-up of 30.2 months, revealing similar rates of early complications and one-year patient survival (85% for DBD-EC vs. 90% for cDCD).
- The findings suggest that cDCD can be a viable donor option, especially when considering older and more comorbid DBD donors, indicating that recipient characteristics should inform donor selection.
Article Abstract
Background: The persistent shortage of optimal kidney donors and the progressive increase in patients on the waiting list have led to an expansion of the acceptance criteria, such as donors after controlled cardiac death (cDCD) and donors after brain death with expanded criteria (DBD-EC). Some concerns and doubts about survival outcomes achieved with these allografts are still present. Our aim was to compare transplant outcomes from cDCD vs DBD-EC.
Methods: A retrospective single-center observational study including all kidney transplant (KT) donors from all cDCD and DBD-EC (>60 years) from January 2015 to January 2022 was performed. We analyzed clinical characteristics, early clinical outcomes, and patient and graft survival rates.
Results: 129 cDCD and 166 DBD-EC KT recipients were included. The median follow-up was 30,2 months. DBD-EC were older and had more comorbidities than cDCD. KTs from cDCD and DBD-EC showed similar rates of delayed graft function and primary nonfunction. Patient survival at 1 year was similar (85% DBD-EC vs 90% cDCD, P = .32). Death-censored graft survival at 1 year was similar among young cDCD (18-59 years) and elderly DBD (60-69 years; 97% vs 92.3%, P = .2). Recipient age and expanded criteria in KT from cDCD were related to worse early graft outcomes. The outcomes achieved with KT from cDCD were similar to those observed in older and more comorbid DBD donors. This assumption is worth consideration when choosing the most suitable donor for each recipient.
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| http://dx.doi.org/10.1016/j.transproceed.2022.09.010 | DOI Listing |
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