AI Article Synopsis
- The WHO's 2016 classification introduced "diffuse midline glioma, H3 K27M-mutant" as a distinct tumor type found in the central nervous system (CNS).
- A case study presented a 16-year-old girl with a glioblastoma showing an H3 K27M mutation in a non-midline location (left temporal stem), which is unusual.
- The findings suggest that H3 K27M mutations should be considered in glioblastomas outside of midline areas, expanding the criteria for diagnosis and understanding of tumor characteristics.
Article Abstract
The WHO classification of tumors of the CNS in 2016 defined "diffuse midline glioma, H3 K27M-mutant" as a new tumor entity locating in the CNS midline. However, the H3 K27M-mutation in "non-midline" glioblastoma are rare and their characteristics have been rarely reported. A 16-year-old girl presented a hyper-intense lesion at her left temporal stem on T2WI, FLAIR and DWI. Biopsy was performed and molecular pathological diagnosis was glioblastoma with H3 K27M-mutant. Accordingly, the possibility of H3 K27M-mutant should be examined not only for diffuse glioma without IDH mutation that develops at a midline location, but also in non-midline locations.
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| http://dx.doi.org/10.1016/j.neucie.2021.06.008 | DOI Listing |
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